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Progressive multifocal leukoencephalopathy developing after obinutuzumab treatment for chronic lymphocytic leukemia

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References

  1. Goede V, Fischer K, Busch R, Engelke A, Eichhorst B, Wendtner CM, Chagorova T, de la Serna J, Dilhuydy MS, Illmer T, Opat S, Owen CJ, Samoylova O, Kreuzer KA, Stilgenbauer S, Dohner H, Langerak AW, Ritgen M, Kneba M, Asikanius E, Humphrey K, Wenger M, Hallek M (2014) Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med 370(12):1101–1110. https://doi.org/10.1056/NEJMoa1313984

    Article  CAS  PubMed  Google Scholar 

  2. Raisch DW, Rafi JA, Chen C, Bennett CL (2016) Detection of cases of progressive multifocal leukoencephalopathy associated with new biologicals and targeted cancer therapies from the FDA’s adverse event reporting system. Expert Opin Drug Saf 15(8):1003–1011. https://doi.org/10.1080/14740338.2016.1198775

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Edelmann J, Gribben JG (2016) Obinutuzumab for the treatment of indolent lymphoma. Future Oncol 12(15):1769–1781. https://doi.org/10.2217/fon-2016-0084

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Fernandez O (2013) Best practice in the use of natalizumab in multiple sclerosis. Ther Adv Neurol Disord 6(2):69–79. https://doi.org/10.1177/1756285612470401

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Vlatko Pejsa.

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VP, ML, and ZP have received a speaker honorarium from Roche. Other authors declare that they have no conflict of interest.

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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.

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Patient’s family provided informed consent for publishing.

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Pejsa, V., Lucijanic, M., Jonjic, Z. et al. Progressive multifocal leukoencephalopathy developing after obinutuzumab treatment for chronic lymphocytic leukemia. Ann Hematol 98, 1509–1510 (2019). https://doi.org/10.1007/s00277-018-3552-x

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  • DOI: https://doi.org/10.1007/s00277-018-3552-x

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