References
Goede V, Fischer K, Busch R, Engelke A, Eichhorst B, Wendtner CM, Chagorova T, de la Serna J, Dilhuydy MS, Illmer T, Opat S, Owen CJ, Samoylova O, Kreuzer KA, Stilgenbauer S, Dohner H, Langerak AW, Ritgen M, Kneba M, Asikanius E, Humphrey K, Wenger M, Hallek M (2014) Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med 370(12):1101–1110. https://doi.org/10.1056/NEJMoa1313984
Raisch DW, Rafi JA, Chen C, Bennett CL (2016) Detection of cases of progressive multifocal leukoencephalopathy associated with new biologicals and targeted cancer therapies from the FDA’s adverse event reporting system. Expert Opin Drug Saf 15(8):1003–1011. https://doi.org/10.1080/14740338.2016.1198775
Edelmann J, Gribben JG (2016) Obinutuzumab for the treatment of indolent lymphoma. Future Oncol 12(15):1769–1781. https://doi.org/10.2217/fon-2016-0084
Fernandez O (2013) Best practice in the use of natalizumab in multiple sclerosis. Ther Adv Neurol Disord 6(2):69–79. https://doi.org/10.1177/1756285612470401
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VP, ML, and ZP have received a speaker honorarium from Roche. Other authors declare that they have no conflict of interest.
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Pejsa, V., Lucijanic, M., Jonjic, Z. et al. Progressive multifocal leukoencephalopathy developing after obinutuzumab treatment for chronic lymphocytic leukemia. Ann Hematol 98, 1509–1510 (2019). https://doi.org/10.1007/s00277-018-3552-x
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DOI: https://doi.org/10.1007/s00277-018-3552-x