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Geriatric screening tools predict survival outcomes in older patients with diffuse large B cell lymphoma

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Abstract

The proportion of elderly patients with diffuse large B cell lymphoma (DLBCL) appears to be increasing, with outcomes varying widely because of the patients’ heterogeneity. Geriatric assessment is used to predict prognosis in elderly patients with DLBCL, but the utility of two simple screening tools for patients with DLBCL, the Flemish version of the Triage Risk Screening Tool (fTRST) and G8, has remained to be elucidated. We retrospectively assessed patients using fTRST and G8, and evaluated the impacts of the scores on survival outcomes in older patients with newly diagnosed DLBCL. A total of 59 patients aged 65 years or older and who were diagnosed with DLBCL were included. The median age was 77 years (range, 65–91 years), and the initial treatments were R-CHOP (63%) and R-THPCOP (31%). The estimated 2-year overall survival (OS) rate was significantly lower in patients with abnormal fTRST scores (≥ 2; N = 17) than in those with normal fTRST scores (< 2; N = 42): (50.5% (95% CI, 22.7–73.0%) vs. 82.2% (95% CI, 63.8–91.8%), P = 0.007). The estimated 2-year OS rate was significantly lower also in patients with abnormal G8 scores (≤ 14; N = 38) than in those with normal G8 scores (> 14; N = 21): (66.1% (95% CI, 46.7–79.5%) vs. 86.8% (95% CI, 55.7–96.7%), P = 0.03, respectively). These associations were independently significant after adjusting for other significant factors by multivariate analysis. These results suggest that the easy-to-use geriatric screening tools, fTRST and G8, have strong prognostic value for OS in older patients with DLBCL.

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Acknowledgments

The authors would like to thank all paramedic staff members at Tachikawa Hospital for their excellent care of the patients and their families.

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Authors and Affiliations

  1. Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Tachikawa Hospital, 4-2-22 Nishiki-cho, Tachikawa-shi, Tokyo, 190-8531, Japan

    Masatoshi Sakurai, Daiki Karigane, Hidenori Kasahara, Tomohiko Tanigawa, Akaru Ishida, Hiroshi Murakami, Masao Kikuchi & Sumiko Kohashi

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  1. Masatoshi Sakurai
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  2. Daiki Karigane
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Correspondence to Masatoshi Sakurai.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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Sakurai, M., Karigane, D., Kasahara, H. et al. Geriatric screening tools predict survival outcomes in older patients with diffuse large B cell lymphoma. Ann Hematol 98, 669–678 (2019). https://doi.org/10.1007/s00277-018-3551-y

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