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References
Berentsen S, Tjønnfjord GE (2012) Diagnosis and treatment of cold agglutinin mediated autoimmune hemolytic anemia. Blood Rev 26:107–115. https://doi.org/10.1016/j.blre.2012.01.002
Berentsen S, Ulvestad E, Langholm R, Beiske K, Hjorth-Hansen H, Ghanima W, Sørbø JH, Tjønnfjord GE (2006) Primary chronic cold agglutinin disease: a population based clinical study of 86 patients. Haematologica 91:460–466
Berentsen S, Randen U, Oksman M, Birgens H, Tvedt THA, Dalgaard J, Galteland E, Haukås E, Brudevold R, Sørbø JH, Næss IA, Malecka A, Tjønnfjord GE (2017) Bendamustine plus rituximab for chronic cold agglutinin disease: results of a Nordic prospective multicenter trial. Blood 130:537–541. https://doi.org/10.1182/blood-2017-04-778175
Wong EK, Kavanagh D (2015) Anticomplement C5 therapy with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Transl Res 165:306–320. https://doi.org/10.1016/j.trsl.2014.10.010
Hillmen P, Hall C, Marsh JC, Elebute M, Bombara MP, Petro BE et al (2004) Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med 350:552–559. https://doi.org/10.1056/NEJMoa031688
Hillmen P, Young NS, Schubert J, Brodsky RA, Socié G, Muus P et al (2006) The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med 355:1233–1243. https://doi.org/10.1056/NEJMoa061648
Shapiro R, Chin-Yee I, Lam S (2015) Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity. Clin Case Rep 3:942–944. https://doi.org/10.1002/ccr3.399
Roth A, Hüttmann A, Rother RP, Dührsen U, Philipp T (2009) Long-term efficacy of the complement inhibitor eculizumab in cold agglutinin disease. Blood 113:3885–3886. https://doi.org/10.1182/blood-2009-01-196329
Gupta N, Wang ES (2014) Long-term response of refractory primary cold aggulutinin disease to eculizumab therapy. Ann Hematol 93:343–344. https://doi.org/10.1007/s00277-013-1800-7
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Makishima, K., Obara, N., Ishitsuka, K. et al. High efficacy of eculizumab treatment for fulminant hemolytic anemia in primary cold agglutinin disease. Ann Hematol 98, 1031–1032 (2019). https://doi.org/10.1007/s00277-018-3521-4
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DOI: https://doi.org/10.1007/s00277-018-3521-4