Annals of Hematology

, Volume 97, Issue 8, pp 1501–1504 | Cite as

Large granular lymphocytic leukemia-associated peripheral neuropathy

  • Neeraj Y Saini
  • Venu Bathini
Letter to the Editor

Dear Editor,

Large granular lymphocytic proliferative disorders (LGLPD) are seldom known to be associated with peripheral neuropathy. We report here a case of mononeuritis multiplex associated with T cell LGL leukemia and review the literature concerning to involvement of peripheral nervous system in LGLPD.

A 58-year-old right-handed Caucasian male with history of hypertension and GERD presented with chronology of events starting 2 weeks earlier with left foot drop; a few days later, he developed difficulty pronouncing certain syllables (“p” as “f”) and lastly went on to develop insidious left facial numbness and weakness on the day of presentation to emergency department. Pertinent physical examination revealed decreased sensation to pinprick and temperature in the left V2 and V3 territory, although sensation to light touch was preserved. Left nasolabial fold was flattened with a decreased smile on the left, and cheek puff strength was also decreased on the left side. However, eye...


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Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Hematology/OncologyUniversity of Massachusetts Medical SchoolWorcesterUSA

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