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Annals of Hematology

, Volume 97, Issue 8, pp 1501–1504 | Cite as

Large granular lymphocytic leukemia-associated peripheral neuropathy

  • Neeraj Y Saini
  • Venu Bathini
Letter to the Editor
  • 116 Downloads

Dear Editor,

Large granular lymphocytic proliferative disorders (LGLPD) are seldom known to be associated with peripheral neuropathy. We report here a case of mononeuritis multiplex associated with T cell LGL leukemia and review the literature concerning to involvement of peripheral nervous system in LGLPD.

A 58-year-old right-handed Caucasian male with history of hypertension and GERD presented with chronology of events starting 2 weeks earlier with left foot drop; a few days later, he developed difficulty pronouncing certain syllables (“p” as “f”) and lastly went on to develop insidious left facial numbness and weakness on the day of presentation to emergency department. Pertinent physical examination revealed decreased sensation to pinprick and temperature in the left V2 and V3 territory, although sensation to light touch was preserved. Left nasolabial fold was flattened with a decreased smile on the left, and cheek puff strength was also decreased on the left side. However, eye...

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Bobker DH, Deloughery TG (1993) Natural killer cell leukemia presenting with a peripheral neuropathy. Neurology 43:1853–1854CrossRefPubMedGoogle Scholar
  2. 2.
    Au W-Y, Mak W, Ho S-L, Leung S-Y, Kwong Y-L (2004) Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia. Neurology 63:588–589CrossRefPubMedGoogle Scholar
  3. 3.
    Taniguchi S, Machi M, Ohno Y (1996) Epstein-Barr virus-associated CD3- large granular lymphocyte leukemia presenting with polycranial nerve palsies. Blood 87:4914–4915PubMedGoogle Scholar
  4. 4.
    Tanaka M, Uesugi Y, Tanaka K, Tanno Y, Tsuji S (1994) Leukemic neuropathy. Neurology 44:1554CrossRefPubMedGoogle Scholar
  5. 5.
    Kono I, Takashima T, Tsuda S, Ueda Y, Ijichi T, Fujita N, Araki K, Nakajima K (1994) Multiple cranial neuritis associated with large granular lymphocytosis. Acta Haematol 92:157–159CrossRefPubMedGoogle Scholar
  6. 6.
    Shiozawa S et al Polyarthritis, mononeuritis multiplex and eczematous ulcerative skin rash in a patient with myelodysplastic syndrome and peripheral large granular lymphocytosis. Clin Exp Rheumatol 9:629–633Google Scholar
  7. 7.
    Leitenberg D, Eisen RN, Goldstein JM, Busque L, Rinder HM, Stys P, Katz ME, Gilliland DG, Smith BR (1995) Natural killer cell lymphoproliferative disease associated with neuropathy. Am J Med 99:99–101CrossRefPubMedGoogle Scholar
  8. 8.
    Lackowski D, Koberda JL, DeLoughery TG, So Y (1998) Natural killer cell leukemia as a cause of peripheral neuropathy and meningitis: case report. Neurology 51:640–641CrossRefPubMedGoogle Scholar
  9. 9.
    Rabbani GR, Phyliky RL, Tefferi A (1999) A long-term study of patients with chronic natural killer cell lymphocytosis. Br J Haematol 106:960–966CrossRefPubMedGoogle Scholar
  10. 10.
    Kwong YL, Wong KF (1998) Association of pure red cell aplasia with T large granular lymphocyte leukaemia. J Clin Pathol 51:672–675CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Wex H, Aumann V, Häusler M, Vorwerk P, Mittler U (2005) Chronic natural killer cell lymphocytosis is associated with elevated cytotoxic activity of natural killer cells. J Pediatr Hematol Oncol 27:85–89CrossRefPubMedGoogle Scholar
  12. 12.
    Noguchi M, Yoshita M, Sakai K, Matsumoto Y, Arahata M, Ontachi Y, Takami A, Nakao S, Sato K, Yamada M (2005) Peripheral neuropathy associated with chronic natural killer cell lymphocytosis. J Neurol Sci 232:119–122CrossRefPubMedGoogle Scholar
  13. 13.
    Chee CE, Warrington KJ, Tefferi A (2009) Chronic natural killer-cell lymphocytosis successfully treated with alemtuzumab. Blood 114:3500–3502CrossRefPubMedGoogle Scholar
  14. 14.
    Hickey WF, Ueno K, Hiserodt JC, Schmidt RE (1992) Exogenously-induced, natural killer cell-mediated neuronal killing: a novel pathogenetic mechanism. J Exp Med 176:811–817CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Hematology/OncologyUniversity of Massachusetts Medical SchoolWorcesterUSA

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