Langerhans cell histiocytosis and primary hemophagocytic lymphohistiocytosis with persistent clonal T-large granular lymphocyte proliferation

Letter to the Editor
  • 28 Downloads

Notes

Compliance with ethical standards

The patient’s mother has signed the photography release form/consent.

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Egeler RM, Katewa S, Leenen PJ, Beverley P, Collin M, Ginhoux F, Arceci RJ, Rollins BJ, Steering Committee of the Nikolas Symposium (2016) Langerhans cell histiocytosis is a neoplasm and consequently its recurrence is a relapse: in memory of Bob Arceci. Pediatr Blood Cancer 63:1704–1712CrossRefPubMedGoogle Scholar
  2. 2.
    Hesseling PB, Wessels G, Egeler RM, Rossouw DJ (1995) Simultaneous occurrence of viral-associated hemophagocytic syndrome and Langerhans cell histiocytosis: a case report. Pediatr Hematol Oncol 12:135–141CrossRefPubMedGoogle Scholar
  3. 3.
    Feldman AL, Berthold F, Arceci RJ, Abramowsky C, Shehata BM, Mann KP, Lauer SJ, Pritchard J, Raffeld M, Jaffe ES (2005) Clonal relationship between precursor T-lymphoblastic leukaemia/lymphoma and Langerhans-cell histiocytosis. Lancet Oncol 6:435–437CrossRefPubMedGoogle Scholar
  4. 4.
    Rodig SJ, Payne EG, Degar BA, Rollins B, Feldman AL, Jaffe ES, Androkites A, Silverman LB, Longtine JA, Kutok JL, Fleming MD, Aster JC (2008) Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1. Am J Hematol 83:116–121CrossRefPubMedGoogle Scholar
  5. 5.
    Wada T, Sakakibara Y, Nishimura R, Toma T, Ueno Y, Horita S, Tanaka T, Nishi M, Kato K, Yasumi T, Ohara O, Yachie A (2013) Down-regulation of CD5 expression on activated CD8+ T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations. Hum Immunol 74:1579–1585CrossRefPubMedGoogle Scholar
  6. 6.
    Singleton TP, Yin B, Teferra A, Mao JZ (2015) Spectrum of clonal large granular lymphocytes (LGLs) of αβ T cells: T-cell clones of undetermined significance, T-cell LGL leukemias, and T-cell immunoclones. Am J Clin Pathol 144:137–144CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Carman and Ann Adams Department of Pediatrics, Children’s Hospital of Michigan, Division of Hematology/Oncology, Pediatric Blood and Marrow Transplantation Program, Barbara Ann Karmanos Cancer CenterWayne State University School of MedicineDetroitUSA
  2. 2.Department of PathologyWayne State University School of MedicineDetroitUSA

Personalised recommendations