Annals of Hematology

, Volume 97, Issue 5, pp 899–904 | Cite as

Polyneuropathy and myopathy in beta-thalassemia major patients

  • P. Nemtsas
  • M. Arnaoutoglou
  • V. Perifanis
  • E. Koutsouraki
  • G. Spanos
  • N. Arnaoutoglou
  • P. Chalkia
  • D. Pantelidou
  • A. Orologas
Original Article


The thalassemias are the most common single gene disorder in the world. Nowadays, the average life expectancy of patients in developed countries has increased significantly, while, there was an increase of complications. We aimed to investigate peripheral neuropathy and myopathy in this patient group using a neurophysiological study. We performed nerve conduction studies and electromyography of upper and lower extremities on 36 beta-thalassemia major (β-thal) patients. The electrophysiological findings were correlated with demographic data and laboratory parameters of the disease. Patients with β-thal present polyneuropathy or myopathy at (50%). Polyneuropathy was detected in (38.9%) and myopathy in (27.8%), while polyneuropathy and myopathy were present at (16.7%) with an overlap of the diseases in 1/3 of the patients. There was not a statistically significant correlation of polyneuropathy and myopathy with age, sex, splenectomy, nor with respect to laboratory parameters, hemoglobin, and ferritin. However, there was a statistically significant correlation of polyneuropathy and myopathy with iron overload, as recorded by the magnetic resonance imaging (MRI) of the heart and the liver. Our findings suggest that iron overload plays a key role in the pathogenesis of polyneuropathy and myopathy in β-thal patients, and performing heart and liver MRI for the prediction of such lesions in an annual basis is warranted.


Peripheral neuropathy Electromyography Thalassemia complications Nerve conduction study Neurological complications T2* MRI heart T2* MRI liver 


Compliance with ethical standards

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

277_2018_3251_MOESM1_ESM.pdf (357 kb)
ESM 1 (PDF 356 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.First Department of NeurologyUniversity General Hospital of Thessaloniki AHEPAThessalonikiGreece
  2. 2.First Propedeutic Department of Internal MedicineUniversity General Hospital of Thessaloniki AHEPAThessalonikiGreece
  3. 3.Tomographia Diagnostic CenterThessalonikiGreece
  4. 4.Department of PsychiatryUniversity of OxfordOxfordUK
  5. 5.Thalassemia UnitUniversity General Hospital of Thessaloniki AHEPAThessalonikiGreece

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