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Simultaneous occurrence of two distinct leukemic clones with PML-RARα and RUNX1-RUNX1T1 in a case of acute myeloid leukemia

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References

  1. Arber DA, Orazi A, Hasserjian R et al (2016) The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127(20):2391–2405

    Article  CAS  PubMed  Google Scholar 

  2. Uz B, Eliaçık E, Işık A et al (2013) Co-expression of t(15;17) and t(8;21) in a case of acute Promyelocytic leukemia: review of the literature. Turk J Haematol 30(4):400–404

    Article  PubMed  PubMed Central  Google Scholar 

  3. Stavroyianni N, Kalmantis T, Yataganas X (1999) Simultaneous PML/RARa and AML1/ETO gene rearrangements in a patient with acute myeloid leukemia. Leukemia 13(8):1294–1295

    Article  CAS  PubMed  Google Scholar 

  4. Abreu e Lima RS, Baruffi MR, de Lima AS et al (2005) The co-expression of PML/RAR alpha and AML1/ETO fusion genes is associated with ATRA resistance. Br J Haematol 128(3):407–409

    Article  PubMed  Google Scholar 

  5. Movafagh A, Varma N, Varma S (1996) Co-expression of two FAB-specific chromosome changes, t(15;17) and t(8;21), in a case of acute promyelocytic leukemia. Ann Hematol 72(6):375–377

    Article  CAS  PubMed  Google Scholar 

  6. Neto WK, Serpa M, Sanabani SS et al (2010) Early detection of t(8;21) chromosomal translocations during treatment of PML-RARA positive acute Promyelocytic leukemia: a case study. Clin Med Insights Oncol 4:163–170

    Article  PubMed  PubMed Central  Google Scholar 

  7. Bonomia R, Giordanoa H, Morenoa MP et al (2000) Simultaneous PML/RARalpha and AML1/ETO expression with t(15;17) at onset and relapse with only t(8;21) in an acute promyelocytic leukemia patient. Cancer Genet Cytogenet 123(1):41–43

    Article  Google Scholar 

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Correspondence to Jinlan Pan.

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Shao, H., Yang, Q., Zhang, P. et al. Simultaneous occurrence of two distinct leukemic clones with PML-RARα and RUNX1-RUNX1T1 in a case of acute myeloid leukemia. Ann Hematol 97, 529–531 (2018). https://doi.org/10.1007/s00277-017-3169-5

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  • DOI: https://doi.org/10.1007/s00277-017-3169-5

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