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Systemic trichosporonosis mimicking disseminated varicella zoster viral infection during blinatumomab therapy

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References

  1. Topp MS, Gökbuget N, Stein AS, Zugmaier G, O'Brien S, Bargou RC, Dombret H, Fielding AK, Heffner L, Larson RA, Neumann S, Foà R, Litzow M, Ribera JM, Rambaldi A, Schiller G, Brüggemann M, Horst HA, Holland C, Jia C, Maniar T, Huber B, Nagorsen D, Forman SJ, Kantarjian HM (2015) Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study. Lancet Oncol 16(1):57–66

    Article  CAS  PubMed  Google Scholar 

  2. Kantarjian H, Stein A, Gökbuget N, Fielding AK, Schuh AC, Ribera JM, Wei A, Dombret H, Foà R, Bassan R, Arslan Ö, Sanz MA, Bergeron J, Demirkan F, Lech-Maranda E, Rambaldi A, Thomas X, Horst HA, Brüggemann M, Klapper W, Wood BL, Fleishman A, Nagorsen D, Holland C, Zimmerman Z, Topp MS (2017) Blinatumomab versus chemotherapy for advanced acute lymphoblastic leukemia. N Engl J Med 376(9):836–847

    Article  CAS  PubMed  Google Scholar 

  3. Martinelli G, Boissel N, Chevallier P, Ottmann O, Gökbuget N, Topp MS, Fielding AK, Rambaldi A, Ritchie EK, Papayannidis C, Sterling LR, Benjamin J, Stein A (2017) Complete hematologic and molecular response in adult patients with relapsed/refractory Philadelphia chromosome-positive B-precursor acute lymphoblastic leukemia following treatment with Blinatumomab: results from a phase II, single-arm, multicenter study. J Clin Oncol 35(16):1795–1802

    Article  PubMed  Google Scholar 

  4. Viardot A, Goebeler ME, Hess G, Neumann S, Pfreundschuh M, Adrian N, Zettl F, Libicher M, Sayehli C, Stieglmaier J, Zhang A, Nagorsen D, Bargou RC (2016) Phase 2 study of the bispecific T-cell engager (BiTE) antibody blinatumomab in relapsed/refractory diffuse large B-cell lymphoma. Blood 127(11):1410–1416

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Goebeler ME, Knop S, Viardot A, Kufer P, Topp MS, Einsele H, Noppeney R, Hess G, Kallert S, Mackensen A, Rupertus K, Kanz L, Libicher M, Nagorsen D, Zugmaier G, Klinger M, Wolf A, Dorsch B, Quednau BD, Schmidt M, Scheele J, Baeuerle PA, Leo E, Bargou RC (2016) Bispecific T-cell engager (BiTE) antibody construct blinatumomab for the treatment of patients with relapsed/refractory non-Hodgkin lymphoma: final results from a phase I study. J Clin Oncol 34(10):1104–1111

    Article  CAS  PubMed  Google Scholar 

  6. Vogt N, Heß K, Bialek R, Buerke B, Brüggemann M, Topp MS, Groth C, Berdel WE, Lenz G, Stelljes M (2017) Epileptic seizures and rhinocerebral mucormycosis during blinatumomab treatment in a patient with biphenotypic acute leukemia. Ann Hematol 96(1):151–153

    Article  PubMed  Google Scholar 

  7. Arendrup MC, Boekhout T, Akova M, Meis JF, Cornely OA, Lortholary O; European Society of Clinical Microbiology and Infectious Diseases Fungal Infection Study Group; European Confederation of Medical Mycology (2014) ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections. Clin Microbiol Infect 3(20 Suppl):76–98

    Google Scholar 

  8. Ruan SY, Chien JY, Hsueh PR (2009) Invasive trichosporonosis caused by Trichosporon asahii and other unusual Trichosporon species at a medical center in Taiwan. Clin Infect Dis 49(1):e11–e17

    Article  CAS  PubMed  Google Scholar 

  9. Chan JF, Chan TS, Gill H, Lam FY, Trendell-Smith NJ, Sridhar S, Tse H, Lau SK, Hung IF, Yuen KY, Woo PC (2015) Disseminated infections with Talaromyces marneffei in non-AIDS patients given monoclonal antibodies against CD20 and kinase inhibitors. Emerg Infect Dis 21(7):1101–1106

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Ahn IE, Jerussi T, Farooqui M, Tian X, Wiestner A, Gea-Banacloche J (2016) Atypical pneumocystis jirovecii pneumonia in previously untreated patients with CLL on single-agent ibrutinib. Blood 128(15):1940–1943

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Yok-Lam Kwong.

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Chan, T.S.Y., Kwong, YL. Systemic trichosporonosis mimicking disseminated varicella zoster viral infection during blinatumomab therapy. Ann Hematol 97, 371–373 (2018). https://doi.org/10.1007/s00277-017-3153-0

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  • DOI: https://doi.org/10.1007/s00277-017-3153-0

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