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Annals of Hematology

, Volume 96, Issue 10, pp 1763–1765 | Cite as

Frequency of hemoglobin E/β-thalassemia compound heterozygotes with low hemoglobin F phenotype among cases with a diagnosis of hemoglobin E homozygote, determined by high-performance liquid chromatography, in prenatal control program for β-thalassemia

  • Peerapon WongEmail author
  • Arunee Srichaiya
  • Pawanrat Suannum
  • Prissana Charoenporn
  • Sawichayaporn Jermnim
  • Monthira Chan-In
  • Akamon Tapprom
  • Rawisut Deoisares
Letter to the Editor

Dear Editor,

Hemoglobin (Hb) E (HBB:c.79G>A)/β-thalassemia disease is the most common thalassemia syndrome in Southeast Asian countries with a high prevalence of Hb E. Even though patients could present with a wide spectrum of clinical severity, the disease accounts for half of the severe β-thalassemia patients worldwide [1]. Among individuals with a carrier state of β-thalassemia or Hb E and homozygous Hb E who could be at-risk couples for Hb E/β-thalassemia, individuals with Hb E/β-thalassemia themselves, especially with mild severity, may still be able to have their own children and also could be at-risk couples. The problem could occur with few Hb E/β-thalassemia compound heterozygotes who have a very low Hb F phenotype and could be misdiagnosed with Hb E homozygote by Hb analysis [2, 3, 4]. Consequently, if their spouses had inherited Hb E allele, they could be at-risk couples for Hb E/β-thalassemia. To date, there are no data regarding the frequency of Hb E/β-thalassemia cases...

Notes

Funding

This work was supported by a research grant from the Faculty of Medicine, Naresuan University.

Compliance with ethical standards

The study was approved by the institutional ethical committee.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Peerapon Wong
    • 1
    Email author
  • Arunee Srichaiya
    • 1
  • Pawanrat Suannum
    • 1
  • Prissana Charoenporn
    • 1
  • Sawichayaporn Jermnim
    • 1
  • Monthira Chan-In
    • 1
  • Akamon Tapprom
    • 1
  • Rawisut Deoisares
    • 1
  1. 1.Thalassemia Research Unit, Faculty of MedicineNaresuan UniversityPhitsanulokThailand

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