Skip to main content
SpringerLink
Log in

Advanced chronic myelomonocytic leukemia in elderly and frail patients managed by azacitidine in the field of clinical practice

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW (2016) The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127(20):2391–2405

    Article  CAS  PubMed  Google Scholar 

  2. Solary E, Itzykson R (2017) How I treat chronic myelomonocytic leukemia. Blood

  3. Alfonso A, Montalban-Bravo G, Takahashi K, Jabbour EJ, Kadia T, Ravandi F, Cortes J, Estrov Z, Borthakur G, Pemmaraju N, Konopleva M, Bueso-Ramos C, Pierce S, Kantarjian H, Garcia-Manero G (2017) Natural history of chronic myelomonocytic leukemia treated with hypomethylating agents. Am J Hematol. doi:10.1002/ajh.24735

  4. Costa R, Abdulhaq H, Haq B, Shadduck RK, Latsko J, Zenati M, Atem FD, Rossetti JM, Sahovic EA, Lister J (2011) Activity of azacitidine in chronic myelomonocytic leukemia. Cancer 117(12):2690–2696

    Article  CAS  PubMed  Google Scholar 

  5. Pleyer L, Germing U, Sperr WR, Linkesch W, Burgstaller S, Stauder R, Girschikofsky M, Schreder M, Pfeilstocker M, Lang A, Sliwa T, Geissler D, Schlick K, Placher-Sorko G, Theiler G, Thaler J, Mitrovic M, Neureiter D, Valent P, Greil R (2014) Azacitidine in CMML: matched-pair analyses of daily-life patients reveal modest effects on clinical course and survival. Leuk Res 38(4):475–483

    Article  CAS  PubMed  Google Scholar 

  6. Fianchi L, Criscuolo M, Breccia M, Maurillo L, Salvi F, Musto P, Mansueto G, Gaidano G, Finelli C, Aloe-Spiriti A, Santini V, Greco M, Hohaus S, Leone G, Voso MT (2013) High rate of remissions in chronic myelomonocytic leukemia treated with 5- azacytidine: results of an Italian retrospective study. Leuk Lymphoma 54(3):658–661

    Article  CAS  PubMed  Google Scholar 

  7. Adès L, Sekeres MA, Wolfromm A, Teichman ML, Tiu RV, Itzykson R, Maciejewski JP, Dreyfus F, List AF, Fenaux P, Komrokji RS (2013) Predictive factors of response and survival among chronic myelomonocytic leukemia patients treated with azacitidine. Leuk Res 37(6):609–613

    Article  PubMed  Google Scholar 

  8. Niscola P, Tendas A, Scaramucci L, Giovannini M, Piccioni D, de Fabritiis P (2014) Acute myeloid leukemia arising from chronic myelomonocytic leukemia during hypomethylating therapy. Blood Res 49(1):65–66

    Article  PubMed  PubMed Central  Google Scholar 

  9. Such E, Germing U, Malcovati L, Cervera J, Kuendgen A, Della Porta MG, Nomdedeu B, Arenillas L, Luño E, Xicoy B, Amigo ML, Valcarcel D, Nachtkamp K, Ambaglio I, Hildebrandt B, Lorenzo I, Cazzola M, Sanz G (2013) Development and validation of a prognostic scoring system for patients with chronic myelomonocytic leukemia. Blood 121(15):3005–15

  10. Savona MR, Malcovati L, Komrokji R, Tiu RV, Mughal TI, Orazi A, Kiladjian JJ, Padron E, Solary E, Tibes R, Itzykson R, Cazzola M, Mesa R, Maciejewski J, Fenaux P, Garcia-Manero G, Gerds A, Sanz G, Niemeyer CM, Cervantes F, Germing U, Cross NC (2015) List AF; MDS/MPN International Working Group. An international consortium proposal of uniform response criteria for myelodysplastic/myeloproliferative neoplasms (MDS/MPN) in adults. Blood 125(12):1857–1865

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Haematology Unit, S. Eugenio Hospital, Rome, Italy

    Pasquale Niscola, Andrea Tendas, Elisabetta Abruzzese, Tommaso Caravita, Luca Cupelli, Marco Giovannini, Laura Scaramucci, Agostina Siniscalchi, Monika Malgorzata Trawinska & Paolo de Fabritiis

Authors
  1. Pasquale Niscola
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrea Tendas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Elisabetta Abruzzese
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tommaso Caravita
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Luca Cupelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marco Giovannini
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Laura Scaramucci
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Agostina Siniscalchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Monika Malgorzata Trawinska
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Paolo de Fabritiis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pasquale Niscola.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Niscola, P., Tendas, A., Abruzzese, E. et al. Advanced chronic myelomonocytic leukemia in elderly and frail patients managed by azacitidine in the field of clinical practice. Ann Hematol 96, 1591–1593 (2017). https://doi.org/10.1007/s00277-017-3064-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-017-3064-0

Search

Navigation