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Clinical-associated characteristics and microbiological features of bloodstream nontyphoidal salmonella infection in adult patients receiving allogeneic hematopoietic stem cell transplantation

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Abstract

Bloodstream nontyphoidal salmonella (NTS) infection is rare, but its associated characteristics and microbiological features in immunocompromised patients are worth paying attention to, particularly for those receiving allogeneic hematopoietic stem cell transplantation (SCT). No studies so far have analyzed post-transplant bloodstream NTS infection. Therefore, we reviewed 423 adult patients undergoing allogeneic hematopoietic SCT from 2003 to 2014. Nine out of four hundred twenty-three patients (2.13%) developed post-transplant bloodstream NTS infection, including two patients who had subsequent or combined metastatic infections. The median age at SCT was 35 years (interquartile range, 29–46) among the nine patients with bloodstream NTS infection. Male patients were predominant (78%). The median onset of bloodstream NTS infection was at 315 days after SCT (range, 207–629). Multivariate analysis revealed that extensive chronic graft-versus-host disease (GVHD) (OR 8.054, p = 0.003) and nonmyeloablative transplant conditioning (OR 4.604, p = 0.037) were significant associated characteristics for NTS infection. Currently, there are no published data analyzing and exploring post-transplant bloodstream NTS infections in adult allogeneic hematopoietic SCT. Our study determined the associated characteristics and microbiological features for this infection.

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Acknowledgments

This work was partially supported by grants from the Taipei Veterans General Hospital (V104B-023), the Taiwan Clinical Oncology Research Foundation, the Szu-Yuan Research Foundation of Internal Medicine, and the Chong Hin Loon Memorial Cancer and Biotherapy Research Center, National Yang-Ming University. The funding sources had no role in the study design or conduct or in the decision to submit it for publication.

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Authors and Affiliations

  1. Division of Hematology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China

    Po-Shen Ko, Yao-Chung Liu, Hao-Yuan Wang, Chia-Yun Wu, Chia-Jen Liu, Yuan-Bin Yu, Liang-Tsai Hsiao, Cheng-Hwai Tzeng, Jin-Hwang Liu & Jyh-Pyng Gau

  2. Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China

    Po-Shen Ko, Yao-Chung Liu, Hao-Yuan Wang, Chia-Yun Wu, Nai-Wen Fan, Chia-Jen Liu, Yuan-Bin Yu, Liang-Tsai Hsiao, Tzeon-Jye Chiou, Cheng-Hwai Tzeng, Jin-Hwang Liu & Jyh-Pyng Gau

  3. Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China

    Nai-Wen Fan

  4. Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China

    Tzeon-Jye Chiou

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  1. Po-Shen Ko
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Contributions

Y-CL, P-SK, H-YW, and C-YW had full access to all of the data in the study and take responsibility for the integrity of the data. Y-CL and P-SK wrote the manuscript. P-SK, H-YW, C-YW, Y-CL, and N-WF analyzed the data. J-PG, C-JL, Y-BY, L-TH, T-JC, C-HT, and J-HL finally confirmed the complete data and manuscript.

Corresponding author

Correspondence to Yao-Chung Liu.

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The authors declare that they have no conflict of interest.

Ethical approval

The retrospective review of medical records was approved by the institutional ethical committee in agreement with the Helsinki Declaration of 1975, revised in 2008. For this type of study, formal consent is not required.

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Ko, PS., Liu, YC., Wang, HY. et al. Clinical-associated characteristics and microbiological features of bloodstream nontyphoidal salmonella infection in adult patients receiving allogeneic hematopoietic stem cell transplantation. Ann Hematol 96, 1533–1540 (2017). https://doi.org/10.1007/s00277-017-3054-2

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  • DOI: https://doi.org/10.1007/s00277-017-3054-2

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