Skip to main content
SpringerLink
Log in

Lineage switch from B acute lymphoblastic leukemia to acute monocytic leukemia with persistent t(4;11)(q21;q23) and cytogenetic evolution under CD19-targeted therapy

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Rossi JG, Bernasconi AR, Alonso CN et al (2012) Lineage switch in childhood acute leukemia: an unusual event with poor outcome. Am J Hematol 87:890–897. doi:10.1002/ajh.23266

    Article  PubMed  Google Scholar 

  2. Armstrong SA, Staunton JE, Silverman LB et al (2002) MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 30:41–47. doi:10.1038/ng765

    Article  CAS  PubMed  Google Scholar 

  3. Dorantes-Acosta E, Pelayo R (2012) Lineage switching in acute Leukemias: a consequence of stem cell plasticity? Bone Marrow Res 2012:1–18. doi:10.1155/2012/406796

    Article  Google Scholar 

  4. Batlevi CL, Matsuki E, Brentjens RJ, Younes A (2015) Novel immunotherapies in lymphoid malignancies. Nat Rev Clin Oncol 13:25–40. doi:10.1038/nrclinonc.2015.187

    Article  PubMed  PubMed Central  Google Scholar 

  5. Aldoss I, Bargou RC, Nagorsen D et al (2017) Redirecting T cells to eradicate B-cell acute lymphoblastic leukemia: bispecific T-cell engagers and chimeric antigen receptors. Leukemia 31:777–787. doi:10.1038/leu.2016.391

    Article  CAS  PubMed  Google Scholar 

  6. Gardner R, Wu D, Cherian S et al (2016) Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy. Blood 127:2406–2410

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lin S, Luo RT, Ptasinska A et al (2016) Instructive role of MLL-fusion proteins revealed by a model of t(4;11) pro-B acute lymphoblastic leukemia. Cancer Cell 30:737–749. doi:10.1016/j.ccell.2016.10.008

    Article  CAS  PubMed  Google Scholar 

  8. Zoghbi A, zur Stadt U, Winkler B et al (2017) Lineage switch under blinatumomab treatment of relapsed common acute lymphoblastic leukemia without MLL rearrangement: ZOGHBI et al. Pediatr Blood Cancer:e26594. doi:10.1002/pbc.26594

Download references

Author information

Authors and Affiliations

  1. APHM, Département de Génétique Médicale, Hôpital La Timone, Marseille, France

    Estelle Balducci, John Boudjarane, Emilie Alazard & Marina Lafage-Pochitaloff

  2. APHM, Laboratoire d’Hématologie, Hôpital La Timone, Marseille, France

    Vanessa Nivaggioni, Lakhdar Bouriche, Denis Bernot, Isabelle Arnoux & Marie Loosveld

  3. APHM, Service d’Hématologie et d’Oncologie Pédiatrique, Hôpital La Timone, Marseille, France

    Ilhem Rahal & Gérard Michel

  4. Laboratoire d’Hématologie, CHU Lille, Lille, France

    Nicolas Duployez & Nathalie Grardel

  5. CNRS, INSERM, CIML, Aix Marseille University, Marseille, France

    Bertrand Nadel

Authors
  1. Estelle Balducci
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vanessa Nivaggioni
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. John Boudjarane
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lakhdar Bouriche
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ilhem Rahal
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Denis Bernot
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Emilie Alazard
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Nicolas Duployez
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Nathalie Grardel
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Isabelle Arnoux
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Marina Lafage-Pochitaloff
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Gérard Michel
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Bertrand Nadel
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Marie Loosveld
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marie Loosveld.

Ethics declarations

Informed consent

Informed consent was obtained from the patient described.

Conflict of interest

The authors declare that there are no conflicts of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Balducci, E., Nivaggioni, V., Boudjarane, J. et al. Lineage switch from B acute lymphoblastic leukemia to acute monocytic leukemia with persistent t(4;11)(q21;q23) and cytogenetic evolution under CD19-targeted therapy. Ann Hematol 96, 1579–1581 (2017). https://doi.org/10.1007/s00277-017-3050-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-017-3050-6

Search

Navigation