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Fecal but not serum calprotectin is a potential marker of GVHD after stem cell transplantation

Annals of Hematology volume 96, pages 929–933 (2017)Cite this article

Abstract

Gastrointestinal graft-versus-host disease (GvHD) represents a life-threatening complication after stem cell transplantation. Differential diagnosis between gut GvHD and other causes of diarrhea after HSCT is still subjected to endoscopy and histological findings. The research for a reliable biomarker for gut GvHD might allow an early diagnosis of this condition and a consequent prompt treatment that could reduce unfavorable outcomes. Recently, fecal calprotectin was reported as reliable marker of gut involvement. We would evaluate if serum instead of fecal calprotectin could be considered a possible biomarker of gut GvHD. Serum calprotectin was measured in a cohort of 54 patients submitted to allogeneic stem cell transplantation using ELISA assay. For a subset of 21 patients, calprotectin serum levels were compared with fecal calprotectin detection. Contrary to fecal calprotectin, we found only a trend to high level of serum calprotectin for GvHD development and gut involvement, but statistical difference was not reached. Fecal but not serum calprotectin could be considered as possible biomarker for gut GvHD.

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Acknowledgements

This study was supported by the Centro di Ricerca sulle Cellule Staminali Emopoietiche e le Terapie Cellulari, Università Cattolica del Sacro Cuore in Rome.

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Affiliations

  1. Hematology Department, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy

    Elisabetta Metafuni, Sabrina Giammarco, Daniela Giovanna De Ritis, Monica Rossi, Andrea P. Bacigalupo, Simona Sica & Patrizia Chiusolo

  2. Biochemistry Department, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy

    Teresa De Michele & Cecilia Zuppi

  3. Università Cattolica del Sacro Cuore, Largo Gemelli 8, 00168, Rome, Italy

    Elisabetta Metafuni, Sabrina Giammarco, Daniela Giovanna De Ritis, Monica Rossi, Teresa De Michele, Cecilia Zuppi, Andrea P. Bacigalupo, Simona Sica & Patrizia Chiusolo

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  1. Elisabetta Metafuni
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  2. Sabrina Giammarco
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  3. Daniela Giovanna De Ritis
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  4. Monica Rossi
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  5. Teresa De Michele
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  6. Cecilia Zuppi
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  7. Andrea P. Bacigalupo
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  8. Simona Sica
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  9. Patrizia Chiusolo
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Correspondence to Simona Sica.

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For this type of study, formal consent is not required. This article does not contain any studied with animals performed by any of the authors.

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Metafuni, E., Giammarco, S., De Ritis, D.G. et al. Fecal but not serum calprotectin is a potential marker of GVHD after stem cell transplantation. Ann Hematol 96, 929–933 (2017). https://doi.org/10.1007/s00277-017-2974-1

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  • DOI: https://doi.org/10.1007/s00277-017-2974-1

Keywords

  • Biomarkers
  • Hematological disease
  • Stem cell transplantation
  • GvHD
  • Calprotectin