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Annals of Hematology

, Volume 96, Issue 4, pp 597–603 | Cite as

Circulating microparticles and the risk of thromboembolic events in Egyptian beta thalassemia patients

  • Ilham Youssry
  • Nohair Soliman
  • Mona Ghamrawy
  • Rania Mohamed Samy
  • Amal Nasr
  • Mohamed Abdel Mohsen
  • Mohamed ElShahaat
  • Rayan Bou Fakhredin
  • Ali Taher
Original Article

Abstract

The presence of elevated numbers of circulating microparticles (MPs) has been hypothesized to be responsible for the occurrence of thromboembolic events (TEEs) in thalassemic patients. Our aim is to evaluate the presence and the thrombotic risk of circulating MPs in thalassemia patients and to determine the difference in MPs between β-thalassemia major (β-TM) and thalassemia intermedia (TI). The percentage of the annexin-labeled MPs, platelet-derived MPs (PMPs), erythrocyte-derived MPs (RMPs), and endothelial-derived MPs (EMPs) was measured by flow cytometry, in 87 thalassemia patients (39 β-TM and 48 TI). By multiple regression analysis, we then assessed the various independent risk factors for the occurrence of TEE. The thalassemic patients who experienced TEE had a significantly higher platelet count, higher percentage of annexin-labeled MPs, and higher percentage of PMPs (p value = 0.014, 0.003, and 0.014, respectively). There was no significant difference between β-TM and TI patients at the level of any of the studied MPs. The predictive risk factors for TEE in thalassemic patients were splenectomy, total and direct bilirubin, the RMPs, and the EMPs (OR = 10.07 (CI = 3.7–27.1), 4.3 (CI = 2.1–8.7), 1.4 (CI = 1.5–6.2), 1.6 (CI = 1.1–2.2), 3.0 (CI = 1.9–4.9), respectively). In conclusion, the elevated numbers of circulating MPs is a risk factor for the TEE in thalassemia patients.

Keywords

Thalassemia major Thalassemia intermedia Microparticles Hypercoagulable state 

Notes

Compliance with ethical standards

Patients and/or their guardians gave their informed consent, and the Institutional Review Board (IRB) approved the study.

Financial relationship:

This research had no financial support.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Ilham Youssry
    • 1
  • Nohair Soliman
    • 2
  • Mona Ghamrawy
    • 1
  • Rania Mohamed Samy
    • 2
  • Amal Nasr
    • 2
  • Mohamed Abdel Mohsen
    • 1
  • Mohamed ElShahaat
    • 2
  • Rayan Bou Fakhredin
    • 3
  • Ali Taher
    • 3
  1. 1.Departments of Pediatrics, Faculty of MedicineCairo UniversityCairoEgypt
  2. 2.Clinical Pathology Department, Faculty of MedicineCairo UniversityCairoEgypt
  3. 3.Department of Internal MedicineAmerican University of Beirut Medical CenterBeirutLebanon

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