Skip to main content
SpringerLink
Log in

Localized LECT2 amyloidosis of the adrenal gland with coexisting MGUS: a diagnostic challenge

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Benson MD, James S, Scott K et al (2008) Leukocyte chemotactic factor 2: a novel renal amyloid protein. Kidney Int 74:218–222

    Article  CAS  PubMed  Google Scholar 

  2. Larsen CP, Walker PD, Weiss DT, Solomon A (2010) Prevalence and morphology of leukocyte chemotactic factor 2-associated amyloid in renal biopsies. Kidney Int 77:816–819

    Article  CAS  PubMed  Google Scholar 

  3. Said SM, Sethi S, Valeri AM et al (2014) Characterization and outcomes of renal leukocyte chemotactic factor 2-associated amyloidosis. Kidney Int 86:370–377

    Article  CAS  PubMed  Google Scholar 

  4. Mereuta OM, Theis JD, Vrana JA et al (2014) Leukocyte cell-derived chemotaxin 2 (LECT2)-associated amyloidosis is a frequent cause of hepatic amyloidosis in the United States. Blood 123:1479–1482

    Article  CAS  PubMed  Google Scholar 

  5. Paueksakon P, Fogo AB, Sethi S (2014) Leukocyte chemotactic factor 2 amyloidosis cannot be reliably diagnosed by immunohistochemical staining. Hum Pathol 45:1445–1450

    Article  CAS  PubMed  Google Scholar 

  6. Nagai H, Hamada T, Uchida T et al (1998) Systemic expression of a newly recognized protein, LECT2, in the human body. Pathol Int 48:882–886

    Article  CAS  PubMed  Google Scholar 

  7. Okumura A, Saito T, Otani I et al (2008) Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis. Arthritis Rheum 58:413–421

    Article  CAS  PubMed  Google Scholar 

  8. Lu XJ, Chen J, Yu CH et al (2013) LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor. J Exp Med 210:5–13

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Said SM, Sethi S, Valeri AM et al (2013) Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases. Clin J Am Soc Nephrol 8:1515–1523

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Larsen CP, Kossmann RJ, Beggs ML et al (2014) Clinical, morphologic, and genetic features of renal leukocyte chemotactic factor 2 amyloidosis. Kidney Int 86:378–382

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

The authors do not have any conflicts of interest to report.

Author information

Authors and Affiliations

  1. Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Boston, MA, USA

    Trevor E. Angell

  2. Division of Hematology/Oncology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA

    Abhisek Swaika, Neha Sood & Sikander Ailawadhi

  3. Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Melanie Goldfarb

  4. Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Imran Siddiqi

Authors
  1. Trevor E. Angell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Abhisek Swaika
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Neha Sood
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Melanie Goldfarb
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Imran Siddiqi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sikander Ailawadhi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sikander Ailawadhi.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Angell, T.E., Swaika, A., Sood, N. et al. Localized LECT2 amyloidosis of the adrenal gland with coexisting MGUS: a diagnostic challenge. Ann Hematol 94, 1603–1604 (2015). https://doi.org/10.1007/s00277-015-2419-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-015-2419-7

Keywords

Search

Navigation