Skip to main content
Log in

HFE hemochromatosis: influence of dietary iron intake on the iron overload of C282Y homozygous patients

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Allen KJ, Gurrin LC, Constantine CC et al (2008) Iron-overload-related disease in HFE hereditary hemochromatosis. N Engl J Med 358:221–230. doi:10.1056/NEJMoa073286

    Article  CAS  PubMed  Google Scholar 

  2. Bacon BR, Britton RS (2008) Clinical penetrance of hereditary hemochromatosis. N Engl J Med 358:291–292. doi:10.1056/NEJMe078215

    Article  CAS  PubMed  Google Scholar 

  3. Rochette J, Le Gac G, Lassoued K et al (2010) Factors influencing disease phenotype and penetrance in HFE haemochromatosis. Hum Genet 128:233–248. doi:10.1007/s00439-010-0852-1

    Article  CAS  PubMed  Google Scholar 

  4. Scotet V, Mérour M-C, Mercier A-Y et al (2003) Hereditary hemochromatosis: effect of excessive alcohol consumption on disease expression in patients homozygous for the C282Y mutation. Am J Epidemiol 158:129–134. doi:10.1093/aje/kwg123

    Article  PubMed  Google Scholar 

  5. Moretti D, van Doorn GM, Swinkels DW, Melse-Boonstra A (2013) Relevance of dietary iron intake and bioavailability in the management of HFE hemochromatosis: a systematic review. Am J Clin Nutr 98:468–479. doi:10.3945/ajcn.112.048264

    Article  CAS  PubMed  Google Scholar 

  6. Aranda N, Viteri FE, Montserrat C, Arija V (2010) Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain. Ann Hematol 89:767–773. doi:10.1007/s00277-010-0901-9

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. EASL (2010) EASL clinical practice guidelines for HFE hemochromatosis. J Hepatol 53:3–22. doi:10.1016/j.jhep.2010.03.001

    Article  Google Scholar 

  8. Bacon BR, Adams PC, Kowdley KV et al (2011) Diagnosis and management of hemochromatosis: 2011 Practice Guideline by the American Association for the Study of Liver Diseases. Hepatology 54:328–343. doi:10.1002/hep.24330

    Article  PubMed Central  PubMed  Google Scholar 

  9. Adams PC, Barton JC (2010) How I treat hemochromatosis. Blood 116:317–325. doi:10.1182/blood-2010-01-261875

    Article  CAS  PubMed  Google Scholar 

  10. Nicolas G, Viatte L, Lou D-Q et al (2003) Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nat Genet 34:97–101. doi:10.1038/ng1150

    Article  CAS  PubMed  Google Scholar 

Download references

Author contributions

Philippe Saliou and Virginie Scotet did the concept and design, analysis and interpretation of data and drafting of the manuscript. Céline Tripogney and Brigitte Chanu did the inclusion of patients and acquisition of data. Isabelle Gourlaouen did the realisation of genetic testing. Marie-Christine Mérour did the entry and management of data. Gérald Le Gac and Jean-Baptiste Nousbaum did the critical revision of the manuscript for important intellectual content. Claude Férec did the study supervision

Conflict of interest

The authors declare they have no conflict of interest.

Additional information

The study was approved by an ethics committee. Informed consent was obtained from all patients for being included in the study.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Philippe Saliou.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Saliou, P., Le Gac, G., Mérour, MC. et al. HFE hemochromatosis: influence of dietary iron intake on the iron overload of C282Y homozygous patients. Ann Hematol 94, 1225–1227 (2015). https://doi.org/10.1007/s00277-015-2343-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-015-2343-x

Keywords

Navigation