Skip to main content
SpringerLink
Log in

Alpha thalassemia trait masquerading as hemoglobin H disease due to co-existing primary myelofibrosis

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Chen FE, Ooi C, Ha SY, Cheung BM, Todd D, Liang R et al (2000) Genetic and clinical features of hemoglobin H disease in Chinese patients. N Engl J Med 343:544–550

    Article  CAS  PubMed  Google Scholar 

  2. Ramensky V, Bork P, Sunyaev S (2002) Human non-synonymous SNPs: server and survey. Nucleic Acids Res 30:3894–3900

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Patrinos GP, Giardine B, Riemer C, Miller W, Chui DHK, Anagnou NP et al (2004) Improvements in the HbVar database of human hemoglobin variants and thalassemia mutations for population and sequence variation studies. Nucleic Acids Res 32(Database issue):D537–D541

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  4. Srivorakun H, Fucharoen G, Puangplruk R, Kheawon N, Fucharoen S (2011) Complex interaction of hemoglobin (Hb) Nakhon Ratchasima [alpha63(E12)Ala– > Val], a novel alpha2-globin chain variant with Hb E [beta26(B8)Glu– > Lys] and a deletional alpha(+)-thalassemia. Eur J Haematol 87:68–72

    Article  CAS  PubMed  Google Scholar 

  5. Thillet J, Blouquit Y, Perrone F, Rosa J (1977) Hemoglobin Pontoise alpha63 Ala replaced by Asp(E12). A new fast moving variant. Biochim Biophys Acta 491:16–22

    Article  CAS  PubMed  Google Scholar 

  6. Klampfl T, Gisslinger H, Harutyunyan AS, Nivarthi H, Rumi E, Milosevic JD et al (2013) Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med 369:2379–2390

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Pathology, Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, China

    Chi-Chiu So & Amy Y. Chan

  2. Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, SAR, China

    Joyce C. Chan

  3. Department of Clinical and Molecular Pathology, Hong Kong Sanatorium and Hospital, Hong Kong, SAR, China

    Edmond S. Ma

Authors
  1. Chi-Chiu So
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amy Y. Chan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joyce C. Chan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Edmond S. Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chi-Chiu So.

Additional information

Informed consent was obtained from all patients for being included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

So, CC., Chan, A.Y., Chan, J.C. et al. Alpha thalassemia trait masquerading as hemoglobin H disease due to co-existing primary myelofibrosis. Ann Hematol 94, 875–877 (2015). https://doi.org/10.1007/s00277-014-2265-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-014-2265-z

Keywords

Search

Navigation