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Mantle cell lymphoma epidemiology: a population-based study in France

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Abstract

Only limited population-based data are available on mantle cell lymphoma (MCL), a relatively rare and aggressive mature B cell non-Hodgkin lymphoma (NHL) entity. We conducted an epidemiological study based on the three French registries devoted to haematological malignancies over the period 2002–2006. Main clinical features and management characteristics were collected. Incidence and survival rates were estimated, and independent prognostic factors were analysed. MCL was diagnosed in 135 patients between 2002 and 2006. Seventy-four percent of patients were men. Age-standardised incidence rate of MCL (per 100,000) was 1.1 in men and 0.26 in women. Median age at diagnosis was 72 years (range 30–92). Advanced-stage (III or IV) disease was diagnosed in 81.5 % of patients, and 55 % of them were identified as high risk according to MCL International Prognostic Index (MIPI). Median net survival time was 41 months (95 % confidence interval (CI), 38–62). Main independent prognostic factors were age at diagnosis, performance status and use of rituximab in first-line treatment. Median overall survival was 36 months (95 % CI, 27–40) for high MIPI and 60 months (95 % CI, 35–74) for low/intermediate MIPI patients (p = 0.02). This study confirms that MCL remains an aggressive NHL with a median overall survival less than 4 years and demonstrates that the use of rituximab has modified overall survival duration.

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Abbreviations

CI:

Confidence interval

ECOG:

Eastern Cooperative Oncology Group

HR:

Hazard ratio

ICD-O:

International Classification of Diseases for Oncology

INSEE:

French National Institute of Statistics and Economic Studies

LDH:

Lactate dehydrogenase

MCL:

Mantle cell lymphoma

MIPI:

MCL International Prognostic Index

NHL:

Non-Hodgkin lymphoma

SEER:

Surveillance Epidemiology and End Results

WASR:

World age-standardised rate

WBC:

White blood cell

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Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Service d’Évaluation Médicale et d’Épidémiologie, Centre Hospitalier Universitaire de Nantes, Nantes, France

    Christophe Leux

  2. Registre des Hémopathies Malignes de Côte d’Or, EA 4184, Réseau REPIH, Université de Bourgogne, Dijon, France

    Marc Maynadié & Aurélie Herry

  3. Registre des Hémopathies Malignes de Basse-Normandie, Réseau REPIH, Caen, France

    Xavier Troussard & Quentin Cabrera

  4. Registre des Hémopathies Malignes de la Gironde, Réseau REPIH, Institut Bergonié, Bordeaux, France

    Sandra Le Guyader-Peyrou & Alain Monnereau

  5. Service d’Hématologie Clinique, Hôtel-Dieu, CHU de Nantes, Place Alexis Ricordeau, 44093, Nantes Cedex, France

    Steven Le Gouill

  6. Centre de Recherche en Cancérologie Nantes/Angers, INSERM UMR 892, Universitaire de Nantes, Nantes, France

    Steven Le Gouill

  7. Centre d’Investigation Clinique en Cancérologie (CI2C), Centre Hospitalier Universitaire de Nantes, Nantes, France

    Steven Le Gouill

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  1. Christophe Leux
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  2. Marc Maynadié
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  3. Xavier Troussard
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  4. Quentin Cabrera
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  5. Aurélie Herry
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  7. Steven Le Gouill
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Correspondence to Steven Le Gouill.

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Leux, C., Maynadié, M., Troussard, X. et al. Mantle cell lymphoma epidemiology: a population-based study in France. Ann Hematol 93, 1327–1333 (2014). https://doi.org/10.1007/s00277-014-2049-5

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  • DOI: https://doi.org/10.1007/s00277-014-2049-5

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