Skip to main content

Advertisement

Log in

Extramedullary T-lymphoid blast crisis of an ETV6/ABL1-positive myeloproliferative neoplasm with t(9;12)(q34;p13) and t(7;14)(p13;q11.2)

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. De Braekeleer E, Douet-Guilbert N, Rowe D, Bown N, Morel F, Berthou C, Férec C, De Braekeleer M (2011) ABL1 fusion genes in hematological malignancies: a review. Eur J Haematol 86:361–371

    Article  PubMed  Google Scholar 

  2. Zuna J, Zaliova M, Muzikova K, Meyer C, Lizcova L, Zemanova Z, Brezinova J, Votava F, Marschalek R, Stary J, Trka J (2010) Acute leukemias with ETV6/ABL1 (TEL/ABL) fusion: poor prognosis and prenatal origin. Gene Chromosome Cancer 49:873–884

    Article  CAS  Google Scholar 

  3. O'Brien SG, Vieira SAD, Connors S, Bown N, Chang J, Capdeville R, Melo JV (2002) Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9;12) translocation. Blood 99:3465–3467

    Article  PubMed  Google Scholar 

  4. Barbouti A, Ahlgren T, Johansson B, Höglund M, Lassen C, Turesson I, Mitelman F, Fioretos T (2003) Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate. Br J Haematol 122:85–93

    Article  CAS  PubMed  Google Scholar 

  5. Tirado CA, Sebastian S, Moore JO, Gong JZ, Goodman BK (2005) Molecular and cytogenetic characterization of a novel rearrangement involving chromosomes 9, 12, and 17 resulting in ETV6 (TEL) and ABL fusion. Cancer Genet Cytogenet 157:74–77

    Article  CAS  PubMed  Google Scholar 

  6. Meyer-Monard S, Mühlematter D, Streit A, Chase AJ, Gratwohl A, Cross NCP, Jotterand M, Tichelli A (2005) Broad molecular screening of an unclassifiable myeloproliferative disorder reveals an unexpected ETV6/ABL1 fusion transcript. Leukemia 19:1096–1099

    Article  CAS  PubMed  Google Scholar 

  7. Kelly JC, Shahbazi N, Scheerle J, Jahn J, Suchen S, Christacos NC, Mowrey PN, Witt MH, Hostetter A, Meloni-Ehring AM (2009) Insertion (12;9)(p13;q34q34): a cryptic rearrangement involving ABL1/ETV6 fusion in a patient with Philadelphia-negative chronic myeloid leukemia. Cancer Genet Cytogenet 192:36–39

    Article  CAS  PubMed  Google Scholar 

  8. Perna F, Abdel-Wahab O, Levine RL, Jhanwar SC, Imada K, Nimer SD (2011) ETV6-ABL1-positive “chronic myeloid leukemia”: clinical and molecular response to tyrosine kinase inhibition. Haematologica 96:342–343

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Jackson CC, Medeiros LJ, Miranda RN (2010) 8p11 myeloproliferative syndrome: a review. Hum Pathol 41:461–476

    Article  CAS  PubMed  Google Scholar 

  10. Van Limbergen H, Beverloo HB, van Drunen E, Janssens A, Hählen K, Poppe B, Van Roy N, Marynen P, De Paepe A, Slater R, Speleman F (2001) Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia. Gene Chromosome Cancer 30:274–282

    Article  Google Scholar 

  11. Mitelman F, Johansson B, Mertens F, editors (2013) Mitelman database of chromosome aberrations and gene fusions in cancer. http://cgap.nci.nih.gov/Chromosomes/Mitelman. Accessed 15 Nov 2013

  12. Dyer MJS, Nacheva E, Fischer P, Heward JM, Labastide W, Karpas A (1993) A new human T-cell lymphoma cell line (Karpas 384) of the T-cell receptor gamma/delta lineage with translocation t(7;14)(p13;q11.2). Leukemia 7:1047–1053

    CAS  PubMed  Google Scholar 

  13. Huret J-L (2012) Atlas of genetics and cytogenetics in oncology and hematology. http://atlasgeneticsoncology.org/. Accessed 15 Nov 2013

Download references

Conflict of interest

The authors have no conflicts of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Katsuya Yamamoto.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yamamoto, K., Yakushijin, K., Nakamachi, Y. et al. Extramedullary T-lymphoid blast crisis of an ETV6/ABL1-positive myeloproliferative neoplasm with t(9;12)(q34;p13) and t(7;14)(p13;q11.2). Ann Hematol 93, 1435–1438 (2014). https://doi.org/10.1007/s00277-013-1975-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-013-1975-y

Keywords

Navigation