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Survival benefit with salvage radiotherapy for patients with locoregionally recurrent extranodal NK/T cell lymphoma, nasal type

Annals of Hematology volume 92, pages 325–332 (2013)Cite this article

Abstract

The purposes of this study are to evaluate prognosis in patients with locoregionally recurrent extranodal nasal-type NK/T cell lymphoma (NKTCL) and to determine the value of salvage radiotherapy. Forty-two patients with NKTCL who developed first locoregional recurrence with (n = 13) or without (n = 29) systemic failure were reviewed. Retreatment included chemotherapy (n = 20), radiotherapy (n = 13), and radiotherapy plus chemotherapy (n = 9). Fifteen patients were reirradiated for localized recurrent disease. The 5-year overall survival (OS) rate after recurrence was 40 %, with a median survival of 26 months. The 2-year OS rate and median OS were 68 % and 36 months for locoregional recurrence only, compared with 31 % and 14 months for both locoregional and systemic recurrence, respectively (p = 0.034). Subgroup analysis for patients with localized recurrent disease revealed an improved OS with radiotherapy. The 2-year and 5-year OS rates were 77 and 69 % for radiotherapy, respectively, compared with a 2-year OS rate of 50 % and median OS of 16 months for chemotherapy alone (p = 0.006). Patients with localized recurrence had a better prognosis than those with systemic recurrence. Salvage radiotherapy or reirradiation resulted in a favorable prognosis for patients with localized recurrent disease.

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Acknowledgments

This work was supported by grants from the Ministry of Health of the People’s Republic of China (grant numbers 07090010, 136) and the Capital Health Research and Development Fund (grant numbers 2009–2012).

Conflict of interest

The authors declare that they have no conflict of interest.

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  1. Department of Radiation Oncology, Cancer Hospital and Institute, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, 100021, People’s Republic of China

    Ting Zhao, Ye-Xiong Li, Shu-Lian Wang, Jing Jin, Wei-Hu Wang, Yong-Wen Song, Yue-Ping Liu, Xin-Fan Liu, Hui Fang, Hua Ren, Bo Chen, Shu-Nan Qi, Qing-Feng Liu, Ning-Ning Lu & Zi-Hao Yu

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  1. Ting Zhao
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Correspondence to Ye-Xiong Li.

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Zhao, T., Li, YX., Wang, SL. et al. Survival benefit with salvage radiotherapy for patients with locoregionally recurrent extranodal NK/T cell lymphoma, nasal type. Ann Hematol 92, 325–332 (2013). https://doi.org/10.1007/s00277-012-1611-2

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  • DOI: https://doi.org/10.1007/s00277-012-1611-2

Keywords

  • Chemotherapy
  • Locoregional recurrence
  • NK/T cell lymphoma
  • Prognosis
  • Radiotherapy
  • Reirradiation