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Ophthalmologic outcomes after chemotherapy and/or radiotherapy in non-conjunctival ocular adnexal MALT lymphoma

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Abstract

In the present study, we evaluated the ophthalmologic outcomes of 24 patients who received chemotherapy and/or radiotherapy for the treatment of non-conjunctival ocular adnexal mucosa-associated lymphoid tissue-type (MALT) lymphoma. Ophthalmologic outcomes were assessed in patients who received chemotherapy and/or radiotherapy from March 2004 until May 2010. Outcomes were determined according to common symptoms following chemotherapy and/or radiotherapy, which consisted of decreased visual acuity, dry eye symptoms, retinopathy, optic neuropathy, increased intraocular pressure, and blepharitis. Nine patients received chemotherapy alone, eight patients received radiotherapy alone, and seven patients received chemotherapy with additional radiotherapy (chemoradiation therapy). Patients treated by chemotherapy alone showed better ophthalmologic outcome scores (mean score, 1.56) than those treated by radiation alone or chemoradiation therapy (mean score, 4.01). In conclusion, the treatment of ocular adnexal lymphoma including radiotherapy showed poor ophthalmologic outcomes due to radiation-induced complications. Recently, many new treatment options have emerged, such as immunotherapy or radioimmunotherapy. In the future study, to select a better treatment modality with fewer complications, well-designed prospective trials with ophthalmologic outcomes are needed.

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Funding/support

The authors did not receive any funding or financial support.

Disclosures

The authors do not have anything to disclose. The authors do not have financial interest for the treatment of ocular adnexal lymphoma.

This paper was not presented in any other international meetings.

Competing interests

None to declare. No conflicting relationship exists for any authors.

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Science, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul, 137-701, Republic of Korea

    Ji-Sun Paik, Won-Kyung Cho & Suk-Woo Yang

  2. Department of Hematology, Catholic BMT Center, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul, 137-701, Republic of Korea

    Sung-Eun Lee & Seok-Goo Cho

  3. Department of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Byung-Ock Choi

  4. Department of Radiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Seung-Eun Jung

  5. Department of Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Gyeong-Sin Park

  6. Department of Nuclear Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Sung-Hoon Kim

  7. Catholic University Lymphoma Group, The Catholic University of Korea, Seoul, South Korea

    Ji-Sun Paik, Won-Kyung Cho, Sung-Eun Lee, Byung-Ock Choi, Seung-Eun Jung, Gyeong-Sin Park, Sung-Hoon Kim, Suk-Woo Yang & Seok-Goo Cho

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  1. Ji-Sun Paik
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  2. Won-Kyung Cho
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  9. Seok-Goo Cho
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Corresponding authors

Correspondence to Suk-Woo Yang or Seok-Goo Cho.

Additional information

J.S. Paik and W.K. Cho equally contributed to this study.

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Paik, JS., Cho, WK., Lee, SE. et al. Ophthalmologic outcomes after chemotherapy and/or radiotherapy in non-conjunctival ocular adnexal MALT lymphoma. Ann Hematol 91, 1393–1401 (2012). https://doi.org/10.1007/s00277-012-1469-3

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  • DOI: https://doi.org/10.1007/s00277-012-1469-3

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