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Primary bone marrow diffuse large B cell lymphoma: a case series and review

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Abstract

Diffuse large cell lymphoma involving bone marrow is not uncommon, but primary, de novo, bone marrow diffuse large B cell lymphoma (DLBCL) is rare. To understand the clinical features and outcomes of this distinct entity, we collected 12 cases in 5 years from a single-center database. They accounted for 1.16% of lymphoma, or 2.65% of diffuse large B cell lymphoma. Nine cases presented with fever of unknown origin. Lactate dehydrogenase levels were elevated in all but one case. Nine cases belonged to the high-risk group according to their international prognosis indexes (score 4 or 5). Four patients received no chemotherapy, all of whom died within 1 month. Four patients received cyclophosphamide, adriamycin, vincristine, and prednisolone (CHOP)-like chemotherapy, and their median survival was 13 months. Finally, four patients received rituximab 375 mg/m2 in addition to CHOP-like chemotherapy. All of them had complete remission and three are still alive without relapse. We concluded that primary bone marrow DLBCL is a rare but distinctive subtype of lymphoma. The prognosis for this entity is poor but rituximab-based treatment is promising for improving its outcomes.

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Financial supports

This work is supported by the grant DOH99-TD-C-111-006 from the Department of Health, Executive Yuan, Taiwan.

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Authors and Affiliations

  1. Division of Hematology–Oncology, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei, Taiwan, Republic of China

    Hung Chang, Yu-Shin Hung, Tung-Liang Lin, Po-Nan Wang, Ming-Chung Kuo, Tzung-Chih Tang, Jin-Hou Wu, Po Dunn & Lee-Yung Shih

  2. School of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China

    Hung Chang, Yu-Shin Hung, Tung-Liang Lin, Po-Nan Wang, Ming-Chung Kuo, Tzung-Chih Tang, Jin-Hou Wu, Po Dunn & Lee-Yung Shih

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  1. Hung Chang
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  2. Yu-Shin Hung
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  9. Lee-Yung Shih
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Correspondence to Lee-Yung Shih.

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Chang, H., Hung, YS., Lin, TL. et al. Primary bone marrow diffuse large B cell lymphoma: a case series and review. Ann Hematol 90, 791–796 (2011). https://doi.org/10.1007/s00277-010-1129-4

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  • DOI: https://doi.org/10.1007/s00277-010-1129-4

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