Skip to main content

Advertisement

Log in

Association between acute myeloid leukemia and isochromosome 6p: a case study and review of the literature

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Mertens F, Johansson B, Mitelman F (1994) Isochromosomes in neoplasia. Genes Chromosomes Cancer 10:221–230

    Article  CAS  PubMed  Google Scholar 

  2. Mitelman F, Johansson B, Mertens F (editors). Miteman database of chromosome aberrations in cancer [Internet]. Updated August 14, 2009. Accessed November 9, 2009. Available at: http://cgap.nci.nih.gov/Chromosomes/Mitelman

  3. Santos GC, Zielenska M, Prasad M, Squire JA (2007) Chromosome 6p amplification and cancer progression. J Clin Pathol 60:1–7

    Article  CAS  PubMed  Google Scholar 

  4. Al-Mulla F, Keith WN, Pickford IR, Going JJ, Birnie GD (1999) Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases. Genes Chromosomes Cancer 24:306–314

    Article  CAS  PubMed  Google Scholar 

  5. Bruch J, Schulz WA, Haussler J, Melzner I, Bruderlein S, Moller P, Kemmerling R, Vogel W, Hameister H (2000) Delineation of the 6p22 amplification unit in urinary bladder carcinoma cell lines. Cancer Res 60:4526–4530

    CAS  PubMed  Google Scholar 

  6. Marchio A, Meddeb M, Pineau P, Danglot G, Tiollais P, Bernheim A, Dejean A (1997) Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer 18:59–65

    Article  CAS  PubMed  Google Scholar 

  7. Partheen K, Levan K, Osterberg L, Helou K, Horvath G (2004) Analysis of cytogenetic alterations in stage III serous ovarian adenocarcinoma reveals a heterogeneous group regarding survival, surgical outcome, and substage. Genes Chromosomes Cancer 40:342–348

    Article  CAS  PubMed  Google Scholar 

  8. Chochi Y, Kawauchi S, Nakao M, Furuya T, Hashimoto K, Oga A, Oka M, Sasaki K (2009) A copy number gain of the 6p arm is linked with advanced hepatocellular carcinoma: an array-based comparative genomic hybridization study. J Pathol 217:677–684

    Article  CAS  PubMed  Google Scholar 

  9. Squire J, Phillips RA, Boyce S, Godbout R, Rogers B, Gallie BL (1984) Isochromosome 6p, a unique chromosomal abnormality in retinoblastoma: verification by standard staining techniques, new densitometric methods, and somatic cell hybridization. Hum Genet 66:46–53

    Article  CAS  PubMed  Google Scholar 

  10. Scaravaglio P, Saglio G, Geuna M, Palestro G, Guglielmelli T, Rege-Cambrin G (1995) Isochromosome 6p and deletion of 6q characterize two related cytogenetic clones in a patient with immunoblastic lymphoma. Cancer Genet Cytogenet 81:179–181

    Article  CAS  PubMed  Google Scholar 

  11. Gallego M. i(6)(p10). Atlas Genet Cytogenet Oncol Haematol 2008. Available at: http://AtlasGeneticsOncology.org/Anomalies/i6p10ID1053.html.

  12. La Starza R, Aventin A, Matteucci C, Crescenzi B, Romoli S, Testoni N, Pierini V, Ciolli S, Sambani C, Locasciulli A, Di Bona E, Lafage-Pochitaloff M, Martelli MF, Marynen P, Mecucci C (2006) Genomic gain at 6p21: a new cryptic molecular rearrangement in secondary myelodysplastic syndrome and acute myeloid leukemia. Leukemia 20:958–964

    Article  PubMed  Google Scholar 

  13. Larson RA, Le Beau MM, Vardiman JW, Testa JR, Golomb HM, Rowley JD (1983) The predictive value of initial cytogenetic studies in 148 adults with acute nonlymphocytic leukemia: a 12-year study (1970–1982). Cancer Genet Cytogenet 10:219–236

    Article  CAS  PubMed  Google Scholar 

  14. Pakkala S, Knuutila S, Helminen P, Ruutu T, Saarinen UM, Peltonen L (1990) DNA-fingerprint changes compared to karyotypes in acute leukemia. Leukemia 4:866–870

    CAS  PubMed  Google Scholar 

  15. Van Limbergen H, Poppe B, Michaux L, Herens C, Brown J, Noens L, Berneman Z, De Bock R, De Paepe A, Speleman F (2002) Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH. Genes Chromosomes Cancer 33:60–72

    Article  PubMed  Google Scholar 

  16. Welborn J (2004) Acquired Robertsonian translocations are not rare events in acute leukemia and lymphoma. Cancer Genet Cytogenet 151:14–35

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgment

This study was supported by the 2005 Inje University research grant.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hye Ran Kim.

Additional information

Seung Hwan Oh and Tae Sung Park equally contributed to this work as first authors.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Oh, S.H., Park, T.S., Kim, S.Y. et al. Association between acute myeloid leukemia and isochromosome 6p: a case study and review of the literature. Ann Hematol 89, 1283–1285 (2010). https://doi.org/10.1007/s00277-010-0940-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-010-0940-2

Keywords

Navigation