Skip to main content
Log in

Therapy of hepatitis C in thalassemia: the influence of iron on achieving sustained viral response

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Taher AT et al (2009) Hepatitis C antiviral response in thalassemia: what is the role of liver iron concentration? Ann Hematol. doi:10.1007/s00277-009-0713-y

  2. Gehrke SG et al (2003) Hemochromatosis and transferrin receptor gene polymorphisms in chronic hepatitis C: impact on iron status, liver injury and HCV genotype. J Mol Med 81(12):780–787. doi:10.1007/s00109-003-0493-0

    Article  CAS  PubMed  Google Scholar 

  3. Desai TK et al (2008) Phlebotomy improves therapeutic response to interferon in patients with chronic hepatitis C: a meta-analysis of six prospective randomized controlled trials. Dig Dis Sci 53(3):815–822. doi:10.1007/s10620-007-9945-7

    Article  CAS  PubMed  Google Scholar 

  4. Fontana RJ et al (2000) Iron reduction before and during interferon therapy of chronic hepatitis C: results of a multicenter, randomized, controlled trial. Hepatology 31(3):730–736. doi:10.1002/hep.510310325

    Article  CAS  PubMed  Google Scholar 

  5. Olynyk JK et al (1995) Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C. Gastroenterology 108(4):1104–1109. doi:10.1016/0016-5085(95)90209-0

    Article  CAS  PubMed  Google Scholar 

  6. Sievert W et al (2002) Hepatic iron overload does not prevent a sustained virological response to interferon-alpha therapy: a long term follow-up study in hepatitis C-infected patients with beta thalassemia major. Am J Gastroenterol 97(4):982–987

    CAS  PubMed  Google Scholar 

  7. Spiliopoulou I et al (1999) Response to interferon alfa-2b therapy in mutitransfused children with beta-thalassemia and chronic hepatitis C. Eur J Clin Microbiol Infect Dis 18(10):709–715. doi:10.1007/s100960050383

    Article  CAS  PubMed  Google Scholar 

  8. Artan R et al (2005) Interferon alpha monotherapy for chronic hepatitis C viral infection in thalassemics and hemodialysis patients. J Chemother 17(6):651–655

    CAS  PubMed  Google Scholar 

  9. Syriopoulou V et al (2005) Sustained response to interferon alpha-2a in thalassemic patients with chronic hepatitis C. A prospective 8-year follow-up study. Haematologica 90(1):129–131

    CAS  PubMed  Google Scholar 

  10. Telfer PT et al (1997) Combination therapy with interferon alpha and ribavirin for chronic hepatitis C virus infection in thalassaemic patients. Br J Haematol 98(4):850–855. doi:10.1046/j.1365-2141.1997.2953112.x

    Article  CAS  PubMed  Google Scholar 

  11. Harmatz P et al (2008) Safety and efficacy of pegylated interferon alpha-2a and ribavirin for the treatment of hepatitis C in patients with thalassemia. Haematol Hematol J 93(8):1247–1251. doi:10.3324/haematol.12352

    Article  CAS  Google Scholar 

  12. Fargion S et al (1997) Liver iron influences the response to interferon alpha therapy in chronic hepatitis C. Eur J Gastroenterol Hepatol 9(5):497–503

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Seyed-Moayed Alavian.

Additional information

Conflict of interest

The authors declare that they have no conflicts of interest relevant to the study.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Alavian, SM., Tabatabaei, SV. Therapy of hepatitis C in thalassemia: the influence of iron on achieving sustained viral response. Ann Hematol 89, 215–216 (2010). https://doi.org/10.1007/s00277-009-0785-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-009-0785-8

Keywords

Navigation