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H. pylori eradication does not reduce paraprotein levels in monoclonal gammopathy of unknown significance (MGUS): a prospective cohort study

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Abstract

Monoclonal gammopathy of unknown significance (MGUS) is a chronic haematological alteration that carries a 1% risk per year of malignant evolution. The origin of this disturbance remains unknown. Previous reports have suggested that a subgroup of patients presenting MGUS might cure after Helicobacter pylori eradication. This study evaluates the effect of H. pylori eradication in a cohort of 30 patients with MGUS. A 7-day clarithromycin-based triple treatment was prescribed to patients with MGUS infected with H. pylori. Quantification of the monoclonal component was performed at inclusion and at least 12 months after treatment. The monoclonal component persisted unchanged in all patients who cured the H. pylori infection.

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References

  1. Blade J (2006) Clinical practice. Monoclonal gammopathy of undetermined significance. N Engl J Med 355:2765–2770, doi:10.1056/NEJMcp052790

    Article  PubMed  CAS  Google Scholar 

  2. Malfertheiner P, Megraud F, O’Morain C, Bazzoli F, El-Omar E, Graham D, Hunt R, Rokkas T, Vakil N, Kuipers EJ (2007) Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut 56:772–781, doi:10.1136/gut.2006.101634

    Article  PubMed  CAS  Google Scholar 

  3. Emilia G, Luppi M, Zucchini P, Morselli M, Potenza L, Forghieri F, Volzone F, Jovic G, Leonardi G, Donelli A, Torelli G (2007) Helicobacter pylori infection and chronic immune thrombocytopenic purpura: long-term results of bacterium eradication and association with bacterium virulence profiles. Blood 110:3833–3841, doi:10.1182/blood-2006-12-063222

    Article  PubMed  CAS  Google Scholar 

  4. Nakamura S, Aoyagi K, Furuse M, Suekane H, Matsumoto T, Yao T, Sakai Y, Fuchigami T, Yamamoto I, Tsuneyoshi M, Fujishima M (1998) B-cell monoclonality precedes the development of gastric MALT lymphoma in Helicobacter pylori-associated chronic gastritis. Am J Pathol 152:1271–1279

    PubMed  CAS  Google Scholar 

  5. Chen LT, Lin JT, Tai JJ, Chen GH, Yeh HZ, Yang SS, Wang HP, Kuo SH, Sheu BS, Jan CM, Wang WM, Wang TE, Wu CW, Chen CL, Su IJ, Whang-Peng J, Cheng AL (2005) Long-term results of anti-Helicobacter pylori therapy in early-stage gastric high-grade transformed MALT lymphoma. J Natl Cancer Inst 97:1345–1353

    Article  PubMed  CAS  Google Scholar 

  6. Wundisch T, Thiede C, Morgner A, Dempfle A, Gunther A, Liu H, Ye H, Du MQ, Kim TD, Bayerdorffer E, Stolte M, Neubauer A (2005) Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradication. J Clin Oncol 23:8018–8024, doi:10.1200/JCO.2005.02.3903

    Article  PubMed  Google Scholar 

  7. Pizzolitto S, Camilot D, DeMaglio G, Falconieri G (2007) Russell body gastritis: expanding the spectrum of Helicobacter pylori—related diseases? Pathol Res Pract 203:457–460, doi:10.1016/j.prp.2007.01.009

    Article  PubMed  Google Scholar 

  8. Wolkersdorfer GW, Haase M, Morgner A, Baretton G, Miehlke S (2006) Monoclonal gammopathy of undetermined significance and Russell body formation in Helicobacter pylori gastritis. Helicobacter 11:506–510, doi:10.1111/j.1523-5378.2006.00443.x

    Article  PubMed  Google Scholar 

  9. Tursi A, Modeo ME (2002) Monoclonal gammopathy of undetermined significance predisposing to Helicobacter pylori-related gastric mucosa-associated lymphoid tissue lymphoma. J Clin Gastroenterol 34:147–149, doi:10.1097/00004836-200202000-00009

    Article  PubMed  Google Scholar 

  10. Malik AA, Ganti AK, Potti A, Levitt R, Hanley JF (2002) Role of Helicobacter pylori infection in the incidence and clinical course of monoclonal gammopathy of undetermined significance. Am J Gastroenterol 97:1371–1374, doi:10.1111/j.1572-0241.2002.05668.x

    Article  PubMed  Google Scholar 

  11. Rajkumar SV, Kyle RA, Plevak MF, Murray JA, Therneau TM (2002) Helicobacter pylori infection and monoclonal gammopathy of undetermined significance. Br J Haematol 119:706–708, doi:10.1046/j.1365-2141.2002.03912.x

    Article  PubMed  Google Scholar 

  12. Papadaki HA, Pontikoglou C, Stavroulaki E, Minadakis G, Eliopoulos DA, Pyrovolaki K, Skordilis P, Eliopoulos GD (2005) High prevalence of Helicobacter pylori infection and monoclonal gammopathy of undetermined significance in patients with chronic idiopathic neutropenia. Ann Hematol 84:317–320, doi:10.1007/s00277-004-0996-y

    Article  PubMed  Google Scholar 

  13. Veneri D, Franchini M, Pizzolo G (2006) Monoclonal gammopathy of undetermined significance and Helicobacter pylori infection. Ann Hematol 85:807–809, doi:10.1007/s00277-006-0155-8

    Article  PubMed  Google Scholar 

  14. Kyle RA (1993) “Benign” monoclonal gammopathy—after 20 to 35 years of follow-up. Mayo Clin Proc 68:26–36

    PubMed  CAS  Google Scholar 

  15. Dominguez-Munoz JE, Leodolter A, Sauerbruch T, Malfertheiner P (1997) A citric acid solution is an optimal test drink in the 13C-urea breath test for the diagnosis of Helicobacter pylori infection. Gut 40:459–462

    PubMed  CAS  Google Scholar 

  16. Wohrer S, Streubel B, Bartsch R, Chott A, Raderer M (2004) Monoclonal immunoglobulin production is a frequent event in patients with mucosa-associated lymphoid tissue lymphoma. Clin Cancer Res 10:7179–7181, doi:10.1158/1078-0432.CCR-04-0803

    Article  PubMed  Google Scholar 

  17. Wohrer S, Troch M, Streubel B, Hoffmann M, Mullauer L, Chott A, Raderer M (2007) Pathology and clinical course of MALT lymphoma with plasmacytic differentiation. Ann Oncol 18:2020–2024, doi:10.1093/annonc/mdm375

    Article  PubMed  CAS  Google Scholar 

  18. McMahon BJ, Hennessy TW, Bensler JM, Bruden DL, Parkinson AJ, Morris JM, Reasonover AL, Hurlburt DA, Bruce MG, Sacco F, Butler JC (2003) The relationship among previous antimicrobial use, antimicrobial resistance, and treatment outcomes for Helicobacter pylori infections. Ann Intern Med 139:463–469

    PubMed  Google Scholar 

  19. Gerrits MM, van Vliet AH, Kuipers EJ, Kusters JG (2006) Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implications. Lancet Infect Dis 6:699–709, doi:10.1016/S1473-3099(06)70627-2

    Article  PubMed  CAS  Google Scholar 

  20. Calvet X, Ducons J, Bujanda L, Bory F, Montserrat A, Gisbert JP (2005) Seven versus ten days of rabeprazole triple therapy for Helicobacter pylori eradication: a multicenter randomized trial. Am J Gastroenterol 100:1696–1701, doi:10.1111/j.1572-0241.2005.50019.x

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

This study has been supported by grants from the Instituto de Salud Carlos III (C03/02 and PI 05/1157 and CIBEREHD) from the Agència de Gestió d’Ajuts Universitaris i de Recerca de la Generalitat de Catalunya (2004ACOM 00041) and from the Societat Catalana de Digestologia.

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Authors and Affiliations

  1. Servei d’Hematologia, Hospital de Sabadell, Institut Universitari Parc Taulí, Universitat Autónoma de Barcelona, Parc Taulí, s/n, 08208 Sabadell, Barcelona, Spain

    Juan-Alfonso Soler & Imma Roig

  2. Digestive Diseases Unit, Hospital de Sabadell, Institut Universitari Parc Taulí, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain

    Jordi Sanchez, Pilar García, Albert Villoria & Xavier Calvet

  3. Nefrology Department, Hospital de Sabadell, Institut Universitari Parc Taulí, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain

    Meritxell Bricullé

  4. Servei de Cirurgia, Hospital de Manresa, Althaia, Manresa, Barcelona, Spain

    Mercé Güell

  5. Laboratori d’Anàlisis Clinics UDIAT-CD Corporació Parc Taulí, Sabadell, Barcelona, Spain

    Antoni Gavarró

  6. CIBEREHD, Instituto de Salud Carlos III, Madrid, Spain

    Jordi Sanchez, Javier P. Gisbert, Pilar García, Albert Villoria & Xavier Calvet

  7. Hospital de la Princesa, Madrid, Spain

    Javier P. Gisbert

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  1. Juan-Alfonso Soler
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  2. Mercé Güell
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Correspondence to Juan-Alfonso Soler.

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Soler, JA., Güell, M., Bricullé, M. et al. H. pylori eradication does not reduce paraprotein levels in monoclonal gammopathy of unknown significance (MGUS): a prospective cohort study. Ann Hematol 88, 769–773 (2009). https://doi.org/10.1007/s00277-008-0684-4

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  • DOI: https://doi.org/10.1007/s00277-008-0684-4

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