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Genetic variation of FUT2 in a Ghanaian population: identification of four novel mutations and inference of balancing selection

Annals of Hematology volume 86, pages 199–204 (2007)Cite this article

Abstract

The FUT2 is rich in polymorphisms that show population-specific patterns in its coding sequence. In this study, we found four novel substitutions in 121 Ghanaian samples. In addition, statistical tests considering population expansion scenarios suggested that balancing selection might be responsible for the genetic diversity of FUT2 in this population.

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Acknowledgments

We thank Prof. Hiroshi Kimura (Chiba Institute of Science, Choshi, Japan) for the helpful advice and support. We thank Ms. Katherine Ono for the English editing of this manuscript.

This work was supported by grants-in-aid for Scientific Research from the Ministry of Education, Science, Culture and Sports of Japan and Mitsui Life Social Welfare Foundation.

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Affiliations

  1. Department of Forensic Medicine and Human Genetics, Kurume University School of Medicine, Kurume, 830-0011, Japan

    Mikiko Soejima, Hao Pang & Yoshiro Koda

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  1. Mikiko Soejima
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  2. Hao Pang
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  3. Yoshiro Koda
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Correspondence to Yoshiro Koda.

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Soejima, M., Pang, H. & Koda, Y. Genetic variation of FUT2 in a Ghanaian population: identification of four novel mutations and inference of balancing selection. Ann Hematol 86, 199–204 (2007). https://doi.org/10.1007/s00277-006-0203-4

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  • DOI: https://doi.org/10.1007/s00277-006-0203-4

Keywords

  • Balancing selection
  • DHPLC
  • FUT2
  • Secretor