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Myelodysplastic syndrome of donor origin subsequent to successful treatment of myeloid/NK-cell precursor leukaemia with allogeneic PBSCT: two very rare conditions in one patient

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Abstract

We report a 36-year-old male with myeloid/natural killer (NK)-cell precursor acute leukaemia with a complex aberrant karyotype, who was treated according to an acute-myeloid-leukaemia (AML) treatment protocol (idarubicine, cytarabine, and etoposide) followed by high-dose cytarabine consolidation and achieved complete remission. He underwent allogeneic matched unrelated donor (MUD) peripheral blood stem-cell transplantation (PBSCT) and remained in remission throughout his remaining life. Seven months posttransplantation, a myelodysplastic syndrome (MDS) with (20q−) of donor origin was diagnosed causing severe thrombocytopenia and finally leading to infection and death. This patient represents one of the few cases published achieving remission for a significant period of time after being diagnosed with myeloid/NK-cell precursor acute leukaemia, a very rare malignant disease. We conclude, despite the fatal outcome due to infection, that allogeneic PBSCT is a therapeutic option for patients with this entity. In addition, the development of a myelodysplastic syndrome of donor origin is extremely rare and only very few cases are published worldwide.

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Notes

  1. Written informed consent of the patient has been obtained.

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Authors and Affiliations

  1. Section Stem Cell- and Immunotherapy, II Medical Department, University Hospitals of Kiel, Dr. Mildred-Scheel-Haus, Schittenhelmstrasse 12, 24105, Kiel, Germany

    C. Beck, A. Humpe & H. A. Horst

  2. Department of Human Genetics, University Hospitals-SH, Schwanenweg 24, 24105, Kiel, Germany

    S. Harder

  3. III Medical Department, University of Ulm, Robert Koch-Strasse 10, 89010, Ulm, Germany

    M. Schmid

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  1. C. Beck
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  2. A. Humpe
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  3. S. Harder
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  4. M. Schmid
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  5. H. A. Horst
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Correspondence to C. Beck.

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Beck, C., Humpe, A., Harder, S. et al. Myelodysplastic syndrome of donor origin subsequent to successful treatment of myeloid/NK-cell precursor leukaemia with allogeneic PBSCT: two very rare conditions in one patient. Ann Hematol 84, 616–618 (2005). https://doi.org/10.1007/s00277-005-1032-6

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  • DOI: https://doi.org/10.1007/s00277-005-1032-6

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