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Myocardial infarction during factor IX infusion in hemophilia B: case report and review of the literature

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Abstract

There are very few reports in the literature of acute myocardial infarction (MI) occurring during infusion of factor concentrates, particularly cryosupernatant in patients with hemophilia B. We describe a case of a 61-year-old man with hemophilia B who suffered an acute MI while receiving cryosupernatant infusion as factor replacement therapy. Cryosupernatant is rich in coagulation factor IX and contains low levels of fibrinogen and von Willebrand’s factor. Factor IX and other factors present in cryosupernatant can possibly become activated during the manufacturing process causing thrombus formation in patients who are prone to it.

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References

  1. Agrawal BL, Zelkowitz L, Hletko P (1981) Acute myocardial infarction in a young hemophiliac patient during therapy with Factor IX concentrate and epsilon aminocaproic acid. J Pediatr 98:931–933

    CAS  PubMed  Google Scholar 

  2. Alsolaiman MM, Chang K, Arjomand H, Oza R, Costacurta G (2000) Acute left anterior descending artery occlusion in a hemophiliac A patient during recombinant factor VIII infusion: treatment with coronary angioplasty. Catheter Cardiovasc Interv 50:468–472

    Article  CAS  PubMed  Google Scholar 

  3. Au WY, Jim MH, Lam CC (2002) Unusual case of coronary artery disease in a patient with severe hemophilia B. Am J Hematol 69:152–153

    Article  CAS  PubMed  Google Scholar 

  4. Bond L, Bevan D (1988) Myocardial infarction in a patient with hemophilia treated with DDAVP. N Engl J Med 318:121

    CAS  Google Scholar 

  5. Borchgrevink CF (1959) Myocardial infarction in a haemophiliac. Lancet 1:1229–1230

    Article  CAS  PubMed  Google Scholar 

  6. Bovenzi F, De Luca L, Signore N, Fusco F, de Luca I (2003) Abciximab for the treatment of an acute thrombotic coronary occlusion during stent implantation in a patient with severe hemophilia B. Ital Heart J 4:728–730

    PubMed  Google Scholar 

  7. Chavin SI, Siegel DM, Rocco TA Jr, Olson JP (1988) Acute myocardial infarction during treatment with an activated prothrombin complex concentrate in a patient with factor VIII deficiency and a factor VIII inhibitor. Am J Med 85:245–249

    CAS  PubMed  Google Scholar 

  8. Chistolini A, Mazzucconi MG, Tirindelli MC, La Verde G, Ferrari A, Mandelli F (1990) Disseminated intravascular coagulation and myocardial infarction in a haemophilia B patient during therapy with prothrombin complex concentrates. Acta Haematol 83:163–165

    Google Scholar 

  9. Fuerth JH, Mahrer P (1981) Myocardial infarction after factor IX therapy. J Am Med Assoc 245:1455–1456

    Article  CAS  Google Scholar 

  10. Gerhard GS, Hoffman SM, Williams EC (1998) Coagulation parameters of ABO group-specific cryosupernatant. Am J Clin Pathol 109:379–386

    CAS  PubMed  Google Scholar 

  11. Green D, Snapper H, Abu-Jawdeh G, Reddy J (1990) Acute myocardial infarction, non-bacterial thrombotic endocarditis, and disseminated intravascular coagulation in a severe hemophiliac. Am J Hematol 35:210–212

    CAS  PubMed  Google Scholar 

  12. Gruen DR, Winchester PH, Brill PW, Ramirez E (1997) Magnetic resonance imaging of myocardial infarction during prothrombin complex concentrate therapy of hemophilia A. Pediatr Radiol 27:271–272

    Article  CAS  PubMed  Google Scholar 

  13. Gruppo RA, Bove KE, Donaldson VH (1983) Fatal myocardial necrosis associated with prothrombin-complex concentrate therapy in hemophilia A. N Engl J Med 309:242–243

    CAS  PubMed  Google Scholar 

  14. Guillet B, Pinganaud C, Proulle V, Dreyfus M, Lambert T (2002) Myocardial infarction occurring in a case of acquired haemophilia during the treatment course with recombinant activated factor VII. Thromb Haemost 88:698–699

    Google Scholar 

  15. Hough RE, Hampton KK, Preston FE, Channer KS, West J, Makris M (2000) Recombinant VIIa concentrate in the management of bleeding following prothrombin complex concentrate-related myocardial infarction in patients with haemophilia and inhibitors. Br J Haematol 111:974–979

    Article  CAS  PubMed  Google Scholar 

  16. Karayalcin G, Goldberg B, Cherrick I, Kurer C, Bierman F, Lanzkowsky P (1993) Acute myocardial infarction complicating prothrombin complex concentrate therapy in an 8-year-old boy with hemophilia A and factor VIII inhibitor. Am J Pediatr Hematol Oncol 15:416–419

    CAS  PubMed  Google Scholar 

  17. Kim HC, Lacy C, Shea S, Saidi P (1981) Haemostatic factors and coronary heart disease (letter). Lancet I:1267

    Google Scholar 

  18. Kohler M (1999) Thrombogenicity of prothrombin complex concentrates. Thromb Res 95 [4 Suppl 1]:S13–S17

    Article  CAS  PubMed  Google Scholar 

  19. Lickfett L, Hagendorff A, Jung W, Pizzulli L, Brackmann HH, Luderitz B (1998) Acute posterior wall infarct after factor VIII concentrate administration to a patient with severe hemophilia A. Dtsch Med Wochenschr 123:658–662

    CAS  PubMed  Google Scholar 

  20. Lowe GDO (2001) Factor IX and thrombosis. Br J Haematol 115:507–513

    Article  CAS  PubMed  Google Scholar 

  21. Meili EO, Straub PW, Lichtlen P, Frick PG (1968) Myocardial infarction in a haemophiliac. Demonstration of coronary sclerosis by selective angiography. Helv Med Acta 34:239–243

    CAS  PubMed  Google Scholar 

  22. Mizon P, Goudemand J, Jude B, Marey A (1992) Myocardial infarction after FEIBA therapy in a hemophilia-B patient with a factor IX inhibitor. Ann Hematol 64:309–311

    CAS  PubMed  Google Scholar 

  23. Paolini R, Viero M, Pietrogrande F, Girolami A (1993) Mild haemophilia A fails to protect from coronary artery disease: the report of two cases. Haematologia (Budap) 25:179–184

    Google Scholar 

  24. Peerlinck K, Vermylen J (1999) Acute myocardial infarction following administration of recombinant activated factor VII (Novo Seven) in a patient with haemophilia A and inhibitor. Thromb Haemost 82:1775–1776

    Google Scholar 

  25. Phillippou H, Adami A, Lane D, et al. (1996) High purity factor IX and prothrombin complex concentrate (PCC): pharmacokinetics and evidence that factor IXa is the thrombogenic trigger in PCC. Thromb Haemost 76:23–28

    PubMed  Google Scholar 

  26. Pinkhas J, Aderka D, Douer D, Bar-Meir S, Shaklai M (1979) Acute myocardial infarction in a hemophiliac. Isr J Med Sci 15:159–161

    CAS  PubMed  Google Scholar 

  27. Praga C, Cortellaro M (1971) Effect of aspirin on platelet aggregation and bleeding time in hemophilia and von Willebrand’s disease. Acta Med Scand 525 [Suppl]:219–221

    CAS  PubMed  Google Scholar 

  28. Rosendaal FR, Varekamp I, Smit C, et al. (1989) Mortality and causes of death in Dutch hemophiliacs, 1973–1986. Br J Haematol 71:71–76

    CAS  PubMed  Google Scholar 

  29. Rosendaal FR, Briet E, Stibbe J, et al. (1990) Hemophilia protects against ischemic heart disease: a study of risk factors. Br J Haematol 75:525–530

    CAS  PubMed  Google Scholar 

  30. Rutherford RB, Ross R (1976) Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate. J Cell Biol 69:196–203

    CAS  PubMed  Google Scholar 

  31. Schimpf K, Zeltsch C, Zeltsch P (1982) Myocardial infarction complicating activated prothrombin complex concentrate substitution in patient with hemophilia A. Lancet 2:1043

    Article  CAS  Google Scholar 

  32. Steinberg MH, Breiling BJ (1973) Vascular lesions in hemophilia B. N Engl J Med 289:592

    CAS  Google Scholar 

  33. Stewart JW, Acheson ED (1957) Atherosclerosis in a hemophilic. Lancet 1:1121–1122

    Article  Google Scholar 

  34. Sullivan DW, Purdy LJ, Billingham M, Glader BE (1984) Fatal myocardial infarction following therapy with prothrombin complex concentrates in a young man with hemophilia A. Pediatrics 74:279–281

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Section of Cardiology, Department of Medicine, Aga Khan University, Stadium Road, Karachi, Pakistan

    Syed Muhammad Najaf & Khawar Kazmi

  2. Department of Medicine, University of Minnesota, USA

    Amyn Malik

  3. Cardiology Division, Queen Elizabeth Health Sciences Center, Dalhousie University, Halifax, Canada

    Ata-ur-Rehman Quraishi

  4. Department of Pathology, Aga Khan University, Karachi, Pakistan

    Ghulam Nabi Kakepoto

Authors
  1. Syed Muhammad Najaf
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  2. Amyn Malik
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  3. Ata-ur-Rehman Quraishi
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  4. Khawar Kazmi
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  5. Ghulam Nabi Kakepoto
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Correspondence to Syed Muhammad Najaf.

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Najaf, S.M., Malik, A., Quraishi, AuR. et al. Myocardial infarction during factor IX infusion in hemophilia B: case report and review of the literature. Ann Hematol 83, 604–607 (2004). https://doi.org/10.1007/s00277-004-0900-9

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  • DOI: https://doi.org/10.1007/s00277-004-0900-9

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