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Coexistence of BCL1/CCND1 and CMYC aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome

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Abstract

A patient with mantle cell lymphoma (MCL) of the pleomorphic blastoid subtype is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient survived only 2 months. Cytogenetically, a t(11;19;14)(q13;q13;q32) was found. Fluorescent in situ hybridization (FISH) and molecular analyses demonstrated involvement of the BCL1/CCND1 locus in a three-way translocation. In addition, subclonal abnormalities of the region 8q24 manifested either as a t(8;22)(q24;q11)/CMYC rearrangement or trisomy 8 were identified. The pathogenetic impact of this very uncommon association of BCL1/CCND1 and CMYC rearrangements in MCL is discussed and the literature is reviewed.

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Acknowledgments

The authors thank R. Siebert (Kiel, Germany) for providing IGL and BCL3 FISH probes. Probes for JH, Cκ, Cλ, and BCL6 were provided by R. Dalla-Favera (University Medical Center, New York, N.Y., USA). The pBcl-1B probe was provided by Y. Tsujimoto (Wistar Institute, Philadelphia, Pa., USA), probe pllq13-7 by T.H. Rabbitts (MRC, Cambridge, UK), probe pHS-11 by P. Gaudray (LGMCH, Nice, France), PRAD1 probe by A. Arnold (Endocrine Unit, Massachusetts General Hospital, Boston, Mass., USA). Probes pαl.4P and pα5B were gifts from T.W. McKeithan (University of Chicago, Chicago, Ill., USA), and the pP20 probe was provided by Dr D. Mathieu-Mahul (Hôpital Saint-Louis, Paris, France). We thank Betty Emanuel for excellent technical assistance and Rita Logist for clerical work. Part of the work was supported by a FWO grant no. G033801N. This text presents research results of the Belgian program of interuniversity poles of attraction initiated by the Belgian state, Prime Minister’s Office, Science Policy Programming. The scientific responsibility is assumed by the authors.

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Authors and Affiliations

  1. Department of Hematology, Clinical Biology and Pathology, Cliniques universitaires UCL St Luc, Brussels, Belgium

    L. Michaux, I. Theate, J.-M. Scheiff, V. Deneys & A. Ferrant

  2. Center for Human Genetics, University of Leuven, Herestraat 49, Leuven, Belgium

    I. Wlodarska, M. Stul & A. Hagemeijer

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  1. L. Michaux
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  2. I. Wlodarska
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  3. I. Theate
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  4. M. Stul
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  5. J.-M. Scheiff
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  6. V. Deneys
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  7. A. Ferrant
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  8. A. Hagemeijer
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Correspondence to A. Hagemeijer.

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Michaux, L., Wlodarska, I., Theate, I. et al. Coexistence of BCL1/CCND1 and CMYC aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome. Ann Hematol 83, 578–583 (2004). https://doi.org/10.1007/s00277-004-0879-2

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  • DOI: https://doi.org/10.1007/s00277-004-0879-2

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