Skip to main content

Advertisement

SpringerLink
Log in

Concomitant occurrence of MALT lymphoma and multiple myeloma

  • Case Report
  • Published:
Annals of Hematology Aims and scope Submit manuscript

An Erratum to this article was published on 15 July 2004

Abstract

The association between multiple myeloma and secondary malignancies is already well established. We report here on the concomitant occurrence of mucosa-associated lymphoid tissue (MALT) lymphoma and multiple myeloma. Despite the fact that both malignancies are mature B-cell neoplasms, the clinical approach to these two types of tumor is completely different. This paper describes the diagnostic approach to this particular case and presents immunophenotypic and molecular cytogenetic data suggesting that the two B-cell malignancies were clonally unrelated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Alexanian R (1980) Localized and indolent myeloma. Blood 56:521–525

    CAS  PubMed  Google Scholar 

  2. Alexanian R, Haut A, Khan AU, et al. (1969) Treatment for multiple myeloma. Combination chemotherapy with different melphalan dose regimens. JAMA 208:1680–1685

    CAS  PubMed  Google Scholar 

  3. Auer IA, Gascoyne RD, Connors JM, et al. (1997) t(11;18)(q21;q21) is the most common translocation in MALT lymphomas. Ann Oncol 8:979–985

    Google Scholar 

  4. Bartl R, Frisch B, Diem H, et al. (1991) Histologic, biochemical, and clinical parameters for monitoring multiple myeloma. Cancer 68:2241–2250

    CAS  PubMed  Google Scholar 

  5. Bergsagel DE, Bailey AJ, Langley GR, MacDonald RN, White DF, Miller AB (1979) The chemotherapy on plasma-cell myeloma and the incidence of acute leukemia. N Engl J Med 301:743–748

    CAS  PubMed  Google Scholar 

  6. Brouet JC, Fermand JP, Laurent G, et al. (1985) The association of chronic lymphocytic leukaemia and multiple myeloma: a study of eleven patients. Br J Haematol 59:55–66

    CAS  PubMed  Google Scholar 

  7. Group TUMFGW (2001) Diagnosis and management of multiple myeloma. Br J Haematol 115:522–540

    Article  PubMed  Google Scholar 

  8. Hammel P, Haioun C, Chaumette MT, et al. (1995) Efficacy of single-agent chemotherapy in low-grade B-cell mucosa-associated lymphoid tissue lymphoma with prominent gastric expression. J Clin Oncol 13:2524–2529

    CAS  PubMed  Google Scholar 

  9. Hoffmann M, Kletter K, Diemling M, et al. (1999) Positron emission tomography with fluorine-18–2-fluoro-2-deoxy-D-glucose (F18-FDG) does not visualize extranodal B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT)-type. Ann Oncol 10:1185–1189

    Article  CAS  PubMed  Google Scholar 

  10. Hyjek E, Smith WJ, Isaacson PG (1988) Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol 19:766–776

    CAS  PubMed  Google Scholar 

  11. Isaacson PG (1995) Primary gastric lymphoma. Br J Biomed Sci 52:291–296

    CAS  PubMed  Google Scholar 

  12. Isaacson PG, Norton AJ (eds) (1994) Extranodal lymphomas. Churchill Livingstone, Edinburgh

  13. Jager G, Neumeister P, Brezinschek R, et al. (2002) Treatment of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type with cladribine: a phase II study. J Clin Oncol 20:3872–3877

    Article  PubMed  Google Scholar 

  14. Kaufmann H, Ackermann J, Nosslinger T, et al. (2001) Absence of clonal chromosomal relationship between concomitant B-CLL and multiple myeloma—a report on two cases. Ann Hematol 80:474–478

    Article  CAS  PubMed  Google Scholar 

  15. Kyle RA, Greipp PR (1980) Smoldering multiple myeloma. N Engl J Med 302:1347–1349

    CAS  PubMed  Google Scholar 

  16. Kyle RA, Pierre RV, Bayrd ED (1970) Multiple myeloma and acute myelomonocytic leukemia. N Engl J Med 283:1121–1125

    CAS  PubMed  Google Scholar 

  17. Law IP, Blom J (1977) Second malignancies in patients with multiple myeloma. Oncology 34:20–24

    CAS  PubMed  Google Scholar 

  18. Martin F, Kearney JF (2002) Marginal-zone B cells. Nat Rev Immunol 2:323–335

    CAS  PubMed  Google Scholar 

  19. Ott G, Katzenberger T, Greiner A, et al. (1997) The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin’s lymphomas of the mucosa-associated lymphoid tissue (MALT-) type. Cancer Res 57:3944–3948

    CAS  PubMed  Google Scholar 

  20. Parsonnet J, Hansen S, Rodriguez L, et al. (1994) Helicobacter pylori infection and gastric lymphoma. N Engl J Med 330:1267–1271

    CAS  PubMed  Google Scholar 

  21. Raderer M, Isaacson PG (2001) Extranodal lymphoma of MALT-type: perspective at the beginning of the 21st century. Expert Rev Anticancer Ther 1:53–64

    CAS  PubMed  Google Scholar 

  22. Raderer M, Jager G, Brugger S, et al. (2003) Rituximab for treatment of advanced extranodal marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue lymphoma. Oncology 65:306–310

    Article  CAS  PubMed  Google Scholar 

  23. Raderer M, Pfeffel F, Pohl G, Mannhalter C, Valencak J, Chott A (2000) Regression of colonic low grade B cell lymphoma of the mucosa associated lymphoid tissue type after eradication of Helicobacter pylori. Gut 46:133–135

    Article  CAS  Google Scholar 

  24. Raderer M, Vorbeck F, Formanek M, et al. (2000) Importance of extensive staging in patients with mucosa-associated lymphoid tissue (MALT)-type lymphoma. Br J Cancer 83:454–457

    CAS  PubMed  Google Scholar 

  25. Streubel B, Lamprecht A, Dierlamm J, et al. (2003) T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma. Blood 101:2335–2339

    Article  CAS  PubMed  Google Scholar 

  26. Wenzel C, Fiebiger W, Dieckmann K, Formanek M, Chott A, Raderer M (2003) Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue of the head and neck area: high rate of disease recurrence following local therapy. Cancer 97:2236–2241

    Article  PubMed  Google Scholar 

  27. Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, Isaacson PG (1991) Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 338:1175–1176

    CAS  PubMed  Google Scholar 

  28. Wozniak R, Beckwith L, Ratech H, Surks MI (1999) Maltoma of the thyroid in a man with Hashimoto’s thyroiditis. J Clin Endocrinol Metab 84:1206–1209

    Article  CAS  PubMed  Google Scholar 

  29. Zojer N, Konigsberg R, Ackermann J, et al. (2000) Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization. Blood 95:1925–1930

    CAS  PubMed  Google Scholar 

  30. Zucca E, Roggero E, Bertoni F, Cavalli F (1997) Primary extranodal non-Hodgkin’s lymphomas. Part 1: gastrointestinal, cutaneous and genitourinary lymphomas. Ann Oncol 8:727–737

    Google Scholar 

  31. Zucca E, Roggero E, Bertoni F, Conconi A, Cavalli F (1999) Primary extranodal non-Hodgkin’s lymphomas. Part 2: head and neck, central nervous system and other less common sites. Ann Oncol 10:1023–1033

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinical Division of Oncology, Department of Medicine I, University Hospital Vienna, Währinger Gürtel 18–20, 1090, Vienna, Austria

    Stefan Wöhrer, Markus Raderer & Johannes Drach

  2. Department of Pathology, University Hospital Vienna, Währinger Gürtel 18–20, 1090, Vienna, Austria

    Berthold Streubel & Andreas Chott

Authors
  1. Stefan Wöhrer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Markus Raderer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Berthold Streubel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Andreas Chott
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Johannes Drach
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stefan Wöhrer.

Additional information

Supported in part by a grant from the Centre of Excellence in Clinical and Experimental Oncology (CLEXO) at the University Hospital Vienna

An erratum to this article can be found at http://dx.doi.org/10.1007/s00277-004-0885-4

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wöhrer, S., Raderer, M., Streubel, B. et al. Concomitant occurrence of MALT lymphoma and multiple myeloma. Ann Hematol 83, 600–603 (2004). https://doi.org/10.1007/s00277-004-0870-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-004-0870-y

Keywords

Search

Navigation