Annals of Hematology

, Volume 82, Issue 8, pp 521–525 | Cite as

Plasmablastic lymphoma presenting in a human immunodeficiency virus-negative patient: a case report

  • D. D. Nguyen
  • B. W. LooJr
  • G. Tillman
  • Y. Natkunam
  • T. M. Cao
  • W. Vaughan
  • R. F. Dorfman
  • D. R. Goffinet
  • C. D. Jacobs
  • R. H. AdvaniEmail author
Case Report


Plasmablastic lymphoma (PBL), an aggressive non-Hodgkin's lymphoma that carries a poor prognosis, previously has been identified almost exclusively in patients infected with the human immunodeficiency virus (HIV). We present a case of a 42-year-old HIV-negative patient presenting with an isolated nasal cavity mass, the typical presentation for PBL. The patient was given systemic chemotherapy, central nervous system prophylaxis, and consolidative locoregional radiotherapy and achieved a complete clinical response. This case suggests PBL should be considered in HIV-negative patients with characteristic findings.


Plasmablastic lymphoma HIV-related non-Hodgkin's lymphoma 


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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • D. D. Nguyen
    • 1
  • B. W. LooJr
    • 2
  • G. Tillman
    • 2
  • Y. Natkunam
    • 3
  • T. M. Cao
    • 4
  • W. Vaughan
    • 5
  • R. F. Dorfman
    • 3
  • D. R. Goffinet
    • 2
  • C. D. Jacobs
    • 1
  • R. H. Advani
    • 1
    Email author
  1. 1.Division of Oncology, Department of MedicineStanford University School of MedicinePalo AltoUSA
  2. 2.Department of Radiation OncologyStanford University School of MedicineStanfordUSA
  3. 3.Department of PathologyStanford University School of MedicineStanfordUSA
  4. 4.Division of Bone Marrow Transplantation, Department of MedicineStanford University School of MedicineStanfordUSA
  5. 5.Department of SurgeryStanford University Medical CenterStanfordUSA

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