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Diffuse large B-cell lymphoma arising from donor lymphoid cells after renal and pancreatic transplantation

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Abstract

A patient with both a renal and pancreatic transplantation developed a diffuse large B-cell lymphoma, Epstein-Barr virus-related, 14 months after the surgical procedure. Tumor was confined to the transplanted organs: head of the pancreas and hilar lymph node of the transplanted kidney. Chimerism analysis demonstrated the tumor origin from donor lymphoid cells. Immunosuppression was discontinued and chemotherapy with cyclophosphamide, hydroxydaunomycin, vincristine, and prednisone (CHOP) was started. However, no response was observed after three courses of this regimen. Finally, a transplantectomy was carried out, followed by rituximab (anti-CD20 antibody), with the patient achieving a complete response (CR). Two years later the patient remains in CR.

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Acknowledgments

This paper has been supported in part by a grant provided by "Marathon TV3, 1999", a nonprofit project raising funds for research in medicine, and FIS no. 00/946 from the Spanish Ministry of Health.

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Authors and Affiliations

  1. Department of Hematology, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain

    M. T. Cibeira, A. Lopez-Guillermo & E. Montserrat

  2. Department of Urology, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Villarroel 170, 08036, Barcelona, Spain

    M. J. Ricart & A. Alcaraz

  3. Hematopathology Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Barcelona, Spain

    D. Colomer, A. Martinez & E. Campo

Authors
  1. M. T. Cibeira
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  2. A. Lopez-Guillermo
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  3. D. Colomer
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  4. M. J. Ricart
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  5. A. Alcaraz
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  6. A. Martinez
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  7. E. Campo
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  8. E. Montserrat
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Correspondence to A. Lopez-Guillermo.

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Cibeira, M.T., Lopez-Guillermo, A., Colomer, D. et al. Diffuse large B-cell lymphoma arising from donor lymphoid cells after renal and pancreatic transplantation. Ann Hematol 82, 131–135 (2003). https://doi.org/10.1007/s00277-002-0591-z

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  • DOI: https://doi.org/10.1007/s00277-002-0591-z

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