Surgical and Radiologic Anatomy

, Volume 40, Issue 6, pp 667–679 | Cite as

Characterization of the perinatal mandible growth pattern: preliminary results

  • F. Remy
  • Y. Godio-Raboutet
  • E. Verna
  • G. Gorincour
  • P. Bonnaure
  • P. Adalian
  • L. Guyot
  • L. Thollon
Original Article



The fetal development of the mandible is nowadays quite understood, and it is already known that craniofacial growth reaches its highest rate during the first 5 years of postnatal life. However, there are very few data focusing on the perinatal period. Thus, the present article is addressing this concern by studying the mandible morphology and its evolution around the birth with a morphometric method.


Thirty-one mandibles modelled in three dimensions from post-mortem CT-scans were analyzed. This sample was divided into two subgroups composed of, respectively, 15 fetuses (aged from 36 gestational weeks), and 16 infants (aged to 12 postnatal weeks). 17 distances, 3 angles, and 8 thicknesses were measured via the prior set of 14 landmarks, illustrating the whole mandible morphology.


Although this methodology may depend on the image reconstruction quality, its reliability was demonstrated with low variability in the results. It highlighted two distinct growth patterns around birth: fetuses mandibles do not significantly evolve during the perinatal period, whereas, from the second postnatal weeks, most of the measurements increased in a homogeneous tendency and in correlation with age.


The protocol developed in this study highlighted the morphologic evolution of the mandible around birth, identifying a different growth pattern from 2 postnatal weeks, probably because of the progressive activation of masticatory muscles and tongue. However, considering the small sample size, these results should be thorough, so identification and management of anatomic abnormalities could eventually be achieved.


Mandible Infant Fetus Mandibular hypoplasia Biometrics Anthropology 



The authors would like to thank Berengere Saliba-Serre for her advices in the statistical analysis of our data.

Author contributions

FR: protocol development, data collection, data analysis, and manuscript writing. YG: project development, data analysis, and manuscript editing. EV: project development and manuscript editing. GG: data collection and manuscript editing. PB: project development and manuscript editing. PA: project development and manuscript editing. LG: project development and manuscript editing. LT: project development, data analysis, and manuscript editing.

Supplementary material

276_2018_2030_MOESM1_ESM.docx (20 kb)
Supplementary material 1 (DOCX 20 KB)


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Copyright information

© Springer-Verlag France SAS, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Aix Marseille Univ, CNRS, EFS, ADESFaculté de Médecine-Secteur NordMarseille Cedex 15France
  2. 2.Aix Marseille Univ, IFSTTAR, LBA UMR_T24Faculté de Médecine-Secteur NordMarseille Cedex 20France
  3. 3.Département d’Imagerie pédiatrique et prénatale, Hôpital des Enfants la TimoneAssistance Publique des Hôpitaux de Marseille-Aix-Marseille UniversitéMarseille Cedex 5France
  4. 4.Laboratoire d’Imagerie Interventionnelle et Expérimentale LiiE, EA 4264Aix-Marseille UniversitéMarseilleFrance
  5. 5.Société YooMedMontpellierFrance
  6. 6.Cabinet de chirurgie dentaireRennesFrance
  7. 7.Service de chirurgie Maxillo-Faciale et Stomatologie, chirurgie plastique et réparatrice, Hôpital NordAssistance Publique des Hôpitaux de Marseille-Aix-Marseille UniversitéMarseille Cedex 20France

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