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Anatomical features of the minor duodenal papilla in pancreas divisum

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Abstract

Background

Clinical expression of pancreas divisum is often explained as a consequence of relative or true stenosis of the minor papilla with dorsal duct obstruction. This anatomo-functional study of the minor papilla in pancreas divisum has included its topographical, functional and structural features.

Materials and methods

The study was carried out on 37 human autopsy specimens of duodenopancreas, which underwent pancreatography, manometrically controlled perfusion and light microscopy.

Results

One pancreas divisum was detected in the study group. In this case, the distances between the minor and the major papilla was 24.0 mm, and between the minor papilla and the superior duodenal flexure 27.4 mm. The minor papilla was patent when perfused under pressure of 10 mmHg, and its light microscopy revealed regular global histological organization with only light fibrosis and no cellular atypia.

Conclusions

The structure and position of the minor papilla in pancreas divisum did not significantly differ from the ones in fused pancreases.

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References

  1. Baldwin WM (1911) The pancreatic ducts in man, together with a study of the microscopical structure of the minor duodenal papilla. Anat Rec 5:197–228

    Article  Google Scholar 

  2. Bardini R, Segalin A, Asolati M (1998) Disconnection of the ampulla of Vater: a new technique for reconstruction. Hepatogastroenterology 45:1479–1481

    PubMed  CAS  Google Scholar 

  3. Bernard JP, Sahel J, Giovannini M, Sarles H (1990) Pancreas divisum is a probable cause of acute pancreatitis: a report of 137 cases. Pancreas 5:248–254

    Article  PubMed  CAS  Google Scholar 

  4. Bhutani MS, Hoffman BJ, Hawes RH (1999) Diagnosis of pancreas divisum by endoscopic ultrasonography. Endoscopy 31:167–169

    Article  PubMed  CAS  Google Scholar 

  5. Bret PM, Reinhold C, Taourel P, Guibaud L, Atri M, Barkun AN et al (1996) Pancreas divisum: evaluation with MR cholangiopancreatography. Radiology 199:99–103

    PubMed  CAS  Google Scholar 

  6. Catanzaro A, Wong RCK (2004) Endoscopic tattooing facilitates repeated localization and endoscopic therapy of a difficult-to-find minor papilla in pancreas divisum. Gastrointest Endosc 58:803–805

    Article  Google Scholar 

  7. Dowdy GS Jr, Waldron GW, Brown WG (1962) Surgical anatomy of the pancreatobiliary ductal system. Arch Surg 84:229–235

    PubMed  Google Scholar 

  8. Frierson HF Jr (1989) The gross anatomy and histology of the gallbladder, extrahepatic bile ducts, Vaterian system and minor papilla. Am J Surg Pathol 13:146–162

    Article  PubMed  Google Scholar 

  9. He H, Lu WF, Ke YZ, Zhang YM (1998) An experimental study in etiologic effect of pancreas divisum on chronic pancreatitis and its pathogenesis. World J Gastroenterol 4:533–535

    PubMed  CAS  Google Scholar 

  10. Helly K (1899) Die Schliessmuskulatur an den Muendungen des Gallen- und der Pankreasgaenge. Arch Mikr Anat 54:614–621

    Article  Google Scholar 

  11. Kamisawa T (2004) Clinical significance of the minor duodenal papilla and accessory pancreatic duct. J Gastroenterol 39:605–615

    Article  PubMed  Google Scholar 

  12. Kim HJ, Kim MH, Lee SK, Seo DW, Kim YT, Lee DK et al (2002) Normal structure, variations, and anomalies of the pancreaticobiliary ducts of Koreans: a nationwide cooperative prospective study. Gastrointest Endosc 55:889–896

    Article  PubMed  Google Scholar 

  13. Kim MH, Lee SS, Kim CD, Lee SK, Kim HJ, Park HJ et al (2001) Incomplete pancreas divisum: Is it a merely normal anatomic variant without clinical implications? Endoscopy 33:778–785

    Article  PubMed  CAS  Google Scholar 

  14. Liou TC, Lin XZ, Chang TT, Lin CY, Lin PW, Jin YT et al (1992) Pancreas divisum with early pancreatic cancer—presenting as chronic obstructive pancreatitis. Pancreas 7:151-156

    Article  Google Scholar 

  15. Lu WF (1998) ERCP and CT diagnosis of pancreas divisum and its relation to etiology of chronic pancreatitis. World J Gastroenterol 4:150–152

    PubMed  Google Scholar 

  16. Matos C, Metens T, Devière J, Delhaye M, Le Moine O, Cremer M (2001) Pancreas divisum: Evaluation with secretin-enhanced magnetic resonance cholangiopancreatography. Gastrointest Endosc 53:728–733

    Article  PubMed  CAS  Google Scholar 

  17. Morise Z, Yamafuji K, Tsuji T, Asami A, Takeshima K, Hayashi N et al (2002) A giant retention cyst of the pancreas (cystic dilatation of the dorsal duct) associated with pancreas divisum. J Gastroenterol 37:1079–1082

    Article  PubMed  Google Scholar 

  18. Nakagawa H, Tsukamoto Y, Naitoe Y (1991) Function of the minor duodenal papilla in humans as determined under duodenoscopy using indigo carmine dye and pH sensor. Endoscopy 23:59–63

    PubMed  CAS  Google Scholar 

  19. Noda Y, Watanabe H, Iwafuchi M, Furuta K, Ishihara N, Satoh M et al (1992) Carcinoids and endocrine cell micronests of the minor and major duodenal papillae. Cancer 70:1825–1833

    Article  PubMed  CAS  Google Scholar 

  20. Nowak A, Nowakowska-Dutawa E, Rybicka J (1990) Patency of the Santorini duct and acute biliary pancreatitis. A prospective ERCP study. Endoscopy 22:124–126

    PubMed  CAS  Google Scholar 

  21. Ohta T, Nagakawa T, Kobayashi H, Kayahara M, Ueno K, Konishi I et al (1991) Histomorphological study on the minor duodenal papilla. Gastroenterol Jpn 26:356–362

    PubMed  CAS  Google Scholar 

  22. Perisic VN, Mihailovic T, Tomomasa T, Milovanovic D, Kuroume T et al (1991) The role of the accessory pancreatic duct of Santorini in pancreatic drainage in children (with emphasis on choledochal cyst patients). Pediatr Radiol 21:258–261

    Article  PubMed  CAS  Google Scholar 

  23. Quest L, Lombard M (2000) Pancreas divisum: opinio divisa. Gut 47:317–319

    Article  PubMed  CAS  Google Scholar 

  24. Reich H (1963) Relation of the duct of Santorini to the pathogenesis of duodenal ulcer. N Engl J Med 269:1119–1120

    Article  PubMed  CAS  Google Scholar 

  25. Satterfield ST, McCarthy JH, Geenen JE, Hogan WJ, Venu RP, Dodds WJ et al (1988) Clinical experience in 82 patients with pancreas divisum: preliminary results of manometry and endoscopic therapy. Pancreas 3:248–253

    Article  PubMed  CAS  Google Scholar 

  26. Stelmasiak M, Karski J (1973) Relation of the accessory pancreatic duct to the duodenal muscularis in man. Folia Morph (Warsz) 32:407–411

    CAS  Google Scholar 

  27. Stern CD (1986) A historical perspective on the discovery of the accessory duct of pancreas, the ampulla of Vater and pancreas divisum. Gut 27:203–212

    Article  PubMed  CAS  Google Scholar 

  28. Stimec B, Alempijevic T, Micev M, Milicevic M, Ille T, Kovacevic N et al (2005) Relationship between papillary fibrosis and patency of the accessory pancreatic duct. Ann Anat 187:99–103

    Article  PubMed  Google Scholar 

  29. Suda K, Mogaki M (1990) Histopathological and immuno-histochemical studies on the minor duodenal papilla. J Jpn Pancreat Soc 4:511–7

    Google Scholar 

  30. Traverso WL, Kozarek RA, Simpson P, Galagan KA (1993) Pancreatic duct obstruction as a potential etiology of pancreatic adenocarcinoma: A clue from pancreas divisum. Am J Gastroenterol 88:117–119

    PubMed  CAS  Google Scholar 

  31. Valverde Barbato de Prates NE, Smanio T, De Maio Domingos M, Ferraz de Carvalho CA et al (1996) “Sphincter” of the minor papilla of the human duodenum. Clin Anat 9:34–40

    Article  Google Scholar 

  32. Warshaw AL, Simeone JF, Schapiro RH, Flavin-Warshaw B (1990) Evaluation and treatment of the dominant dorsal duct syndrome (pancreas divisum redefined). Am J Surg 159:59–66

    Article  PubMed  CAS  Google Scholar 

  33. Wehrmann T, Schmitt T, Seifert H (1999) Endoscopic botulinum toxin injection into the minor papilla for treatment of idiopathic recurrent pancreatitis in patients with pancreas divisum. Gastrointest Endosc 50:545–548

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgement

The authors wish to thank the Serbian Ministry of Science for grant support.

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Correspondence to Bojan Stimec.

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Alempijevic, T., Stimec, B. & Kovacevic, N. Anatomical features of the minor duodenal papilla in pancreas divisum. Surg Radiol Anat 28, 620–624 (2006). https://doi.org/10.1007/s00276-006-0155-3

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  • DOI: https://doi.org/10.1007/s00276-006-0155-3

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