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Hepatic chemoembolization: Effect of intraarterial lidocaine on pain and postprocedure recovery

CardioVascular and Interventional Radiology volume 22, pages 293–297 (1999)Cite this article

Abstract

Purpose: To determine if intraarterial lidocaine reduces pain during and after chemoembolization, and whether it influences postprocedure recovery.

Methods: Two patient cohorts undergoing selective hepatic chemoembolization were compared. Chemoembolization was performed without lidocaine (control group) in 27 patients and intraarterial lidocaine was used (lidocaine group) in 29 similar patients. Objective changes in patient management were assessed. Pain reduction in 31 more procedures with lidocaine (total 60) was assessed and related to tumor type.

Results: During chemoembolization, intraarterial lidocaine reduced the need for additional intravenous analgesics from 69% to 19%. After chemoembolization the mean Dilaudid dose in the first 24 hr was reduced from 9.5 mg to 4.15 mg; accordingly, the mean length of hospital stay was reduced from 67.5 to 53.5 hr. During the day of chemoembolization, the mean oral fluid intake increased from 420 ml (control group) to 487 ml (lidocaine group); the percentage of patients taking solid food on the day of chemoembolization increased from 3% to 43%.

Conclusion: Intraarterial lidocaine during chemoembolization reduces the severity and duration of pain after chemoembolization resulting in faster recovery thus reducing the length of hospitalization.

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Affiliations

  1. Departments of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 1 Deaconess Road, 02215, Boston, MA, USA

    George G. Hartnell, Julia Gates, Jonathan Underhill & David P. Brophy

  2. Departments of Medical Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, 1 Deaconess Road, 02215, Boston, MA, USA

    Keith Stuart

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  1. George G. Hartnell
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  2. Julia Gates
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  3. Keith Stuart
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  4. Jonathan Underhill
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  5. David P. Brophy
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Hartnell, G.G., Gates, J., Stuart, K. et al. Hepatic chemoembolization: Effect of intraarterial lidocaine on pain and postprocedure recovery. Cardiovasc Intervent Radiol 22, 293–297 (1999). https://doi.org/10.1007/s002709900391

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  • DOI: https://doi.org/10.1007/s002709900391

Key words

  • Anesthesia
  • Chemotherapy, complications
  • Embolism, therapeutic
  • Hepatic arteries, therapeutic blockade
  • Liver neoplasms, chemotherapeutic infusion