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Transcatheter arterial infusion therapy in the treatment of advanced pancreatic cancer: A feasibility study

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Abstract

Purpose: To evaluate the effects of transcatheter arterial infusion (TAI) therapy in 18 patients with advanced pancreatic cancer.

Methods: The drugs infused were epirubicin 60 mg, mitomycin C 20 mg, and 5-fluorouracil 500 mg. The efficacy of TAI was evaluated by a tumor marker (CA19-9), computed tomography (CT) findings, and postoperative histopathological specimens.

Results: In 10 of 15 cases, the tumor marker level was decreased after TAI therapy. In 6 of 14 cases, CT showed a decrease in the tumor size, and in 1 case, the tumor disappeared completely. In 6 cases the tumor could be resected. Necrosis, fibrosis, and degeneration of cancer cells were seen in 3 of 4 cases for whom a histopathological evaluation was done. The median survival was 11 months. In 17 patients back pain was the chief complaint, and was reduced to a self-controlled level in 10 patients following TAI therapy. No major complications were encountered.

Conclusion: TAI appears to be an effective palliative treatment for advanced pancreatic cancer.

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Authors and Affiliations

  1. Department of Radiology, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan

    Keiko Shibuya, Yasushi Nagata, Rumi Murata, Takehisa Takagi & Masahiro Hiraoka

  2. Department of Radiology, Kyoto National Hospital, 1-1 Mukaihata-cho, Fukakusa, Hushimi-ku, 612-0861, Kyoto, Japan

    Tuyoshi Itoh & Kaoru Okajima

Authors
  1. Keiko Shibuya
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  2. Yasushi Nagata
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  3. Tuyoshi Itoh
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  4. Kaoru Okajima
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  5. Rumi Murata
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  6. Takehisa Takagi
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  7. Masahiro Hiraoka
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Shibuya, K., Nagata, Y., Itoh, T. et al. Transcatheter arterial infusion therapy in the treatment of advanced pancreatic cancer: A feasibility study. Cardiovasc Intervent Radiol 22, 196–200 (1999). https://doi.org/10.1007/s002709900365

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  • DOI: https://doi.org/10.1007/s002709900365

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