Abstract
Purpose
To describe the feasibility and technique of percutaneous image-guided combined treatment of bone cyst (BC) using cryoablation and bone graft substitute injection.
Materials and Methods
Between July 2019 and January 2022, six consecutive patients (ages between 16 and 33 years) with symptomatic BC in pelvic and lower extremity bones underwent percutaneous image-guided combined treatment using cryoablation and bone graft substitute. To induce bone mineralization as early as possible, the cyst cavity was filled with bone graft substitute. Technical success of the procedure was evaluated, and clinical success was defined as satisfactory clinical symptom relief using visual analogue scale (VAS). Radiologic success was defined as early BC remineralization on radiographic studies. Detailed demographic data with lesion location, size, time to and degree of BC mineralization, complications, clinical outcomes, and radiological follow-up were retrospectively assessed.
Results
Technical success was 100% achieved in all patients. BC mineralization was observed in all patients, with a median time to reach 80% mineralization at 6 months, with one patient reaching 80% at 5 months and another reaching 100% at 3 months. A significant drop in VAS was observed in all patients, reflecting significant pain relief. There were no major complications. The median follow-up period was 31.5 months, with a minimum follow-up of 5 months and a maximum follow-up of 3 years.
Conclusion
Percutaneous image-guided combined treatment with cryoablation and bone graft substitute for symptomatic BC is technically feasible and was safe in this limited series.
References
Deventer N, Deventer N, Gosheger G, de Vaal M, Vogt B, Budny T. Current strategies for the treatment of solitary and aneurysmal bone cysts: a review of the literature. J Bone Oncol. 2021;1(30): 100384.
Arleo TL, Hawkins CM, Fabregas JA, Gill AE. Percutaneous image-guided treatment of aneurysmal bone cysts: is there a superior treatment option? Pediatric Radiol. 2022;24:1–1.
Cazzato RL, Garnon J, Ramamurthy N, Koch G, Tsoumakidou G, Caudrelier J, Arrigoni F, Zugaro L, Barile A, Masciocchi C, Gangi A. Percutaneous image-guided cryoablation: current applications and results in the oncologic field. Med Oncol. 2016;33(12):1–6.
Tsoumakidou G, Too CW, Garnon J, Steib JP, Gangi A. Treatment of a spinal aneurysmal bone cyst using combined image-guided cryoablation and cementoplasty. Skelet Radiol. 2015;44(2):285–9.
Fritz J, Sonnow L, Morris CD. Adjuvant MRI-guided percutaneous cryoablation treatment for aneurysmal bone cyst. Skelet Radiol. 2019;48(7):1149–53.
Griauzde J, Gemmete JJ, Farley F. Successful treatment of a Musculoskeletal Tumor Society grade 3 aneurysmal bone cyst with N-butyl cyanoacrylate embolization and percutaneous cryoablation. J Vasc Interv Radiol. 2015;26(6):905–9.
Van Der Geest IC, De Valk MH, De Rooy JW, Pruszczynski M, Veth RP, Schreuder HW. Oncological and functional results of cryosurgical therapy of enchondromas and chondrosarcomas grade 1. J Surg Oncol. 2008;98(6):421–6.
William G Jr, Einhorn TA, Koval K, McKee M, Smith W, Sanders R, Watson T. Bone grafts and bone graft substitutes in orthopaedic trauma surgery: a critical analysis. JBJS. 2007;89(3):649–58.
Evaniew N, Tan V, Parasu N, Jurriaans E, Finlay K, Deheshi B, Ghert M. Use of a calcium sulfate–calcium phosphate synthetic bone graft composite in the surgical management of primary bone tumors. Orthopedics. 2013;36(2):e216–22.
Kotnis NA, Parasu N, Finlay K, Jurriaans E, Ghert M. Chronology of the radiographic appearances of the calcium sulphate–calcium phosphate synthetic bone graft composite following resection of bone tumours—a preliminary study of the normal post-operative appearances. Skelet Radiol. 2011;40(5):563–70.
Tan V, Evaniew N, Finlay K, Jurriaans E, Ghert M, Deheshi B, Parasu N. Chronology of the radiographic appearances of the calcium sulfate-calcium phosphate synthetic bone graft composite following resection of bone tumors: a follow-up study of postoperative appearances. Can Assoc Radiol J. 2016;67(1):21–7.
Auloge P, Cazzato RL, Rousseau C, Caudrelier J, Koch G, Rao P, Chiang JB, Garnon J, Gangi A. Complications of percutaneous bone tumor cryoablation: a 10-year experience. Radiology. 2019;291(2):521–8.
Meller I, Weinbroum A, Bickels J, Dadia S, Nirkin A, Merimsky O, Issakov J, Flusser G, Marouani N, Cohen N, Kollender Y. Fifteen years of bone tumor cryosurgery: a single-center experience of 440 procedures and long-term follow-up. Eur J Surg Oncol (EJSO). 2008;34(8):921–7.
Gage AA, Guest K, Montes M, Caruana JA, Whalen DA Jr. Effect of varying freezing and thawing rates in experimental cryosurgery. Cryobiology. 1985;22(2):175–82.
Xu G, Yamamoto N, Nojima T, Hayashi K, Takeuchi A, Miwa S, Igarashi K, Tsuchiya H. The process of bone regeneration from devitalization to revitalization after pedicle freezing with immunohistochemical and histological examination in rabbits. Cryobiology. 2020;1(92):130–7.
Tanzawa Y, Tsuchiya H, Shirai T, Hayashi K, Yo Z, Tomita K. Histological examination of frozen autograft treated by liquid nitrogen removed after implantation. J Orthopaed Sci. 2009;14(6):761–8.
Salam AA, Ibbett I, Thani N. Paediatric cranioplasty: a review. Interdiscip Neurosurg. 2018;1(13):59–65.
Flynn JM, Schwend RM. Management of pediatric femoral shaft fractures. JAAOS-J Am Acad Orthop Surg. 2004;12(5):347–59.
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Alkuhaimi, T.S., Alduraywish, I., Alghamdi, T. et al. Feasibility of Percutaneous Image-Guided Combined Treatment of Symptomatic Bone Cyst Using Cryoablation and Bone Graft Substitute. Cardiovasc Intervent Radiol 46, 512–518 (2023). https://doi.org/10.1007/s00270-023-03390-5
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DOI: https://doi.org/10.1007/s00270-023-03390-5