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Current Status of Trans-Arterial Embolization in Pain Management of Musculoskeletal Inflammatory Conditions — An Evidence-Based Review

Abstract

Objective

To summarize the literature on trans-arterial embolization in inflammatory musculoskeletal conditions, focusing on efficacy and safety.

Materials and Methods

PRISMA guidelines were followed. A systematic literature search revealed 19 studies, with a total of 394 participants, eligible for inclusion.

Results

The included studies consisted of case reports/series and non-randomized interventional studies, with knee osteoarthritis and adhesive capsulitis of the shoulder as the most frequent conditions. In all studies except one, pain was reduced up to four years after treatment. All adverse events were transient. Due to high heterogeneity, meta-analysis was not possible.

Conclusion

The included early studies showed encouraging results regarding efficacy and safety. However, randomized, placebo-controlled trials are warranted.

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Funding

This study was not supported by any funding.

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Authors

Contributions

All authors contributed to the study conception and design. The literature search was developed and conducted by first author LH and reviewed and approved by all co-authors. Screening of eligible studies and data extraction were done independently by LH and MT. The first draft of the manuscript was written by LH with supervision by MT and LL. All authors reviewed, edited, and approved the final manuscript.

Corresponding author

Correspondence to Louise Hindsø.

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Hindsø, L., Riis, R.G.C., Hölmich, P. et al. Current Status of Trans-Arterial Embolization in Pain Management of Musculoskeletal Inflammatory Conditions — An Evidence-Based Review. Cardiovasc Intervent Radiol (2021). https://doi.org/10.1007/s00270-021-02948-5

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Keywords

  • Interventional radiology
  • Inflammatory musculoskeletal disorders
  • Trans-arterial embolization
  • Pain management