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Survival Benefit of Radiofrequency Ablation with Intratumoral Cisplatin Administration in a Rabbit VX2 Lung Tumor Model

  • Laboratory Investigation
  • Interventional Oncology
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Abstract

Purpose

This study evaluated the survival benefit of a combination therapy with radiofrequency ablation (RFA) and intratumoral cisplatin (ITC) administration for lung tumors by using a rabbit VX2 tumor model.

Materials and Methods

Experiments were approved by the institutional animal care committee. VX2 tumor suspension was injected into the lungs of Japanese white rabbits under CT guidance to create a lung tumor model. Thirty-two rabbits bearing a transplanted VX2 lung tumor were randomly assigned to four groups of eight: control (untreated); RFA alone; ITC alone; and RFA with ITC. All treatments were performed one week after tumor transplantation. Kaplan–Meier survival curves were compared by the log-rank test.

Results

The median survival time was 24.5 days (range 17–33 days) in the control group, 40 days (30–80 days) in the RFA alone group, 31.0 days (24–80 days) in the ITC alone group, and not reached (53–80 days) in the RFA with ITC group. The median survival was significantly longer with the RFA/ITC combination compared to the control group (P < 0.001), RFA alone (P = 0.034), and ITC alone (P = 0.004). The survival time after RFA alone was also significantly longer than that of the control group (P < 0.001). There was no significant difference in tumor size or the rate of pneumothorax between each group.

Conclusion

RFA prolonged the survival of rabbits with lung VX2 tumors when combined with ITC.

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Funding

This work was supported by JSPS KAKENHI Grant No JP16K10360.

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Authors and Affiliations

  1. Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, Osaka, 545-8585, Japan

    Kazuki Murai, Shinichi Hamamoto, Tomohisa Okuma, Ken Kageyama, Akira Yamamoto, Satoyuki Ogawa, Takehito Nota, Etsuji Sohgawa, Atsushi Jogo & Yukio Miki

Authors
  1. Kazuki Murai
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  2. Shinichi Hamamoto
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  3. Tomohisa Okuma
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  4. Ken Kageyama
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  5. Akira Yamamoto
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  6. Satoyuki Ogawa
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  7. Takehito Nota
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  8. Etsuji Sohgawa
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Correspondence to Shinichi Hamamoto.

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The authors declare that they have no conflict of interest.

Ethical Approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

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Murai, K., Hamamoto, S., Okuma, T. et al. Survival Benefit of Radiofrequency Ablation with Intratumoral Cisplatin Administration in a Rabbit VX2 Lung Tumor Model. Cardiovasc Intervent Radiol 44, 475–481 (2021). https://doi.org/10.1007/s00270-020-02686-0

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  • DOI: https://doi.org/10.1007/s00270-020-02686-0

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