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Peripheral Embolization Using Hydrogel-Coated Coils Versus Fibered Coils: Short-Term Results in an Animal Model

  • Laboratory Investigation
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Abstract

Objectives

To angiographically compare the occlusive effects of hydrocoils and fibered coils in the renal and internal iliac arteries at 24 h and 7 days in the sheep model. To determine the occlusive mechanism by hydrocoils and fibered coils by pathological examination.

Materials and Methods

Two types of peripheral hydrogel-coated and fibered coils similar in diameter and length were compared. The right and left renal arteries were embolized with 0.018-inch detachable hydrocoils or fibered coils in six sheep. Then, the right and left internal iliac arteries were embolized with 0.035-inch pushable hydrocoils or fibered coils. Arterial recanalization was evaluated at 24 h and at 7 days with angiography. At pathology, the surface percentage of thrombus and embolic material (platinum, Dacron fibers and hydrogel) and the presence of inflammation were assessed.

Results

No difference was found between the coils for recanalization at 24 h or 7 days. For hydrocoils, the surface of occlusion corresponded to thrombus for 42% and coil for 58% including 42% of platinum and 16% of hydrogel, respectively. For fibered coils, the surface of occlusion was composed of thrombus for 69% and of platinum and fibers for 31%. The surface percentage occupied by thrombus was significantly lower for hydrocoils than for fibered coils (p = 0.0047). The surface percentage of embolic was also different between the two products (p = 0.049). No degradation of hydrogel was found at any time points.

Conclusion

The percentage of thrombus was significantly less with hydrocoils as compared to fibered coils, which may account for reduced long-term recanalization.

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Authors and Affiliations

  1. Normandie University, UNICAEN, CEA, CNRS, ISTCT-CERVOxy, 14000, Caen, France

    Audrey Fohlen & Jean-Pierre Pelage

  2. Archimmed, 12 rue Charles de Gaulle, 78350, Jouy-en-Josas, France

    Julien Namur, Homayra Ghegediban & Jean-Pierre Pelage

  3. Department of Neuroradiology, Hôpital Lariboisière, Université Paris, 7 rue Ambroise Paré, 75475, Paris Cedex 10, France

    Alexandre Laurent

  4. Department of Pathology, Hôpital Lariboisière, Université Paris, 7 rue Ambroise Paré, 75475, Paris Cedex 10, France

    Michel Wassef

Authors
  1. Audrey Fohlen
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  2. Julien Namur
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  3. Homayra Ghegediban
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  4. Alexandre Laurent
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  5. Michel Wassef
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  6. Jean-Pierre Pelage
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Corresponding author

Correspondence to Jean-Pierre Pelage.

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Conflict of interest

The scientific guarantor of this publication is Jean-Pierre Pelage. The authors of this manuscript declare relationship with the following companies: Audrey Fohlen, Consultant and research grants: Guerbet, Consultant: Cook; Julien Namur, Employee: Archimmed company; Homayra Ghegediban, Employee: Archimmed company; Alexandre Laurent, Consultant: Archimmed company; Michel Wassef, Consultant: Archimmed company; Jean-Pierre Pelage, Consultant and research grants ALN, Archimmed, Cook, Merit Medical, Terumo, Consultant: Boston Scientific, Guerbet, Vascular Solutions.

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Fohlen, A., Namur, J., Ghegediban, H. et al. Peripheral Embolization Using Hydrogel-Coated Coils Versus Fibered Coils: Short-Term Results in an Animal Model. Cardiovasc Intervent Radiol 41, 305–312 (2018). https://doi.org/10.1007/s00270-017-1834-7

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  • DOI: https://doi.org/10.1007/s00270-017-1834-7

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