To identify possible risk factors in predicting clinical outcome in critical limb ischemia (CLI) patients undergoing percutaneous transluminal angioplasty (PTA).
Materials and Methods
PubMed and EMBASE were searched for studies analyzing CLI and clinical outcome after PTA from January 2006 to April 2017. Outcome measures were ulcer healing, amputation free survival (AFS)/limb salvage and overall survival. Data on predictive factors for ulcer healing, AFS/limb salvage and survival were extracted.
Ten articles with a total of 2448 patients were included, all cohorts and based on prospective-designed databases. For ulcers, it seems that complete healing can be achieved in most of the patients within 1 year. No significant predictive factors were found. AFS/limb salvage: AFS rates for 1, 2 and 3 years ranged from 49.5 to 75.2%, 37 to 58% and 22 to 59%, respectively. Limb salvage rates for 1, 2 and 3 years ranged from 71 to 95%, 54 to 93.3% and 32 to 92.7%, respectively. All studies had different univariate and multivariate outcomes for predictive factors; however, age and diabetes were significant predictors in at least three studies. Survival: Survival rates for 1, 2 and 3 years ranged from 65.4 to 91.5%, 45.7 to 76% and 37.3 to 83.1%, respectively. Different predictive factors were found; however, age was found in 2 out of 5 studies reporting on predictive factors.
In several studies two factors, age and diabetes, were found as predictive factors for AFS/limb salvage and survival in patients with CLI undergoing PTA. Therefore, we believe that these factors should be taken into account in future research.
Level of Evidence
Critical limb ischemia (CLI) due to peripheral arterial disease is a condition in which the lower extremity is threatened and is defined by ischemic rest pain, with or without ischemic tissue loss . CLI has a great impact on healthcare and associated healthcare budget . A number of risk factors are known to be associated with the development of CLI, which are diabetes mellitus, smoking, increased age, lipid abnormalities and low ankle-brachial pressure index .
Percutaneous transluminal angioplasty (PTA), with or without stenting, is an alternative approach to surgical bypass as a revascularization method in patients with CLI [5, 6]. Compared to surgery, it involves advantages such as minimal access trauma and shorter hospital stay. Therefore, PTA is more suited and often suggested as first-line therapy for high-risk CLI patients with a lower life expectancy [7,8,9,10].
To identify the effect of PTA, clinical outcomes such as wound healing, amputation free survival (AFS) and survival during follow-up are recorded and presented [11,12,13,14,15,16,17]. However, interpreting these clinical outcomes in this patient group is difficult, because of its heterogeneity in the risk factors such as comorbid diabetes, difference in age, renal failure or lifestyle factors such as smoking and obesity. We often see a discrepancy between a good revascularization result of the PTA, identified on digital subtraction angiography (DSA) and an unexpected poor clinical outcome with early amputation [9, 18, 19]. For future analysis of study results concerning endovascular treatment in CLI patients, it is important to identity which risk factors are associated with poor outcome.
Therefore, the aim of this systematic review was to identify risk factors in predicting poor clinical outcome in patients with CLI undergoing PTA with or without stenting. Drug eluting technologies were not included in the review to try to maintain homogeneity in the study population.
Materials and Methods
This review was conducted according to the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines . The review protocol was not published or registered in advance.
An electronic search was performed in the databases PubMed and EMBASE for studies analyzing CLI and clinical outcome after percutaneous revascularization. The search period was from January 2006 to April 2017. Search terms used for PubMed and EMBASE are listed below.
PubMed “Critical limb ischemia OR critical limb ischemia AND (angioplasty OR endovascular revascularization OR percutaneous intentional extraluminal revascularization OR subintimal OR endovascular therapy) AND (major amputation OR amputation free survival OR death OR ulcer healing OR wound healing OR mortality OR survival) AND Humans”.
Embase: (Critical limb ischamia OR critical limb ischemia) AND (percutaneous transluminal angioplasty balloon OR percutaneous transluminal angioplasty OR angioplasty OR stent OR revascularization) AND mortality OR (amputation OR major amputation OR leg amputation) OR (ulcer healing OR wound healing) OR (survival).
All retrieved articles were checked on title and abstract by one observer (X2). Duplicates, reviews, guidelines, comments, letters to the editor, conferences, case reports, study protocol and articles not containing CLI were excluded.
All remaining articles were also checked on abstract by the same observer (X2). When studies contained less than fifty patients, patients did not receive PTA, the study was retrospective (we considered prospective database as prospective study) or the follow-up period was less than 1 year, these studies were excluded. To avoid exclusion of relevant articles, ambiguous articles were retrieved as full text and treated as potentially eligible articles. The observer double-checked step 2 and was not blinded to author and journal names.
Inclusion of Relevant Articles
Three observers (X1, X2 and X3) independently checked all remaining articles for inclusion and exclusion criteria. Two observers (X1 and X2) each checked half of the relevant articles, and the findings were discussed with observer 3 (X3) who has experience on data extraction of 25 meta-analyses.
The inclusion criteria were as follows: (1) prospective study or prospective database (we considered prospective database as prospective study, hospital billing and other registries as retrospective); (2) patients with CLI as defined by Fontaine class III–IV or Rutherford class IV–VI (rest pain, non-healing ulcer or gangrene); (3) patients underwent (regular) PTA (no drug eluting stents); (4) >50 patients with CLI undergoing PTA; (5) data on outcome were available for at least 1 year of follow-up (outcomes were healing, AFS (major of minor) and overall survival); (6) separate data on CLI and PTA were available (in studies that included a variety of patients or treatments, for example data on CLI patient who underwent PTA or bypass surgery); and (7) finally, data on predictive factors were reported. Exclusion criterion was duplicate data.
Two reviewers (X1, radiologist with experience in extracting data of two reviews and X2, medical student) used a standardized form to extract data independently on study design characteristics, patient selection, baseline patient characteristics, procedure description, angiographic outcomes and complications, follow-up and dropout patients, clinical outcomes and predictive factors. Again, each observer extracted data of half of the articles and were double-checked by the third reviewer with experience on data extraction of 25 meta-analyses.
Study design characteristics The following data on study design characteristics were extracted: (1) study type (cohort, part of RCT or other); (2) study design (single center or multicenter and prospective study or prospective database retrospectively analyzed); (3) setting initiation institute (academic, tertiary or other); (4) department initiation by first author (radiology, surgery or other); (5) period of recruitment; (6) institutional review board approval (approved and informed consent obtained/waived, not approved or unclear); and (7) funding or a potential role of funders in the study (conflict of interest).
Patient selection The following data on patient selection were retrieved: (1) consecutive sample of patients enrolled (yes or no); (2) inclusion and exclusion criteria defined; and (3) spectrum of patients representative for CLI patients normally receiving PTA.
Baseline patient characteristics There were no age limits applied regarding patients. The following data on patient population were extracted: (1) number of patients included in the study and (2) analyzed in the final analysis; (3) age of patients (mean ± SD, median and/or range); (4) male-to-female ratio; (5) smoking (n + percentage); (6) diabetes mellitus (n + percentage); (7) hypertension (n + percentage); (8) dyslipidaemia (n + percentage); (9) renal failure (n + percentage); (10) coronary artery disease (n + percentage); (11) stroke history (n + percentage); (12) BMI < 18,5 kg/m2 (n + percentage); (13) other factors (n + percentage); (14) other baseline characteristics such as ankle-brachial index (ABI), toe pressure (mean ± SD in mmHg), ankle pressure, TcPO2 (mean ± SD in mmHg), ulcer classification (n + percentage), Fontaine classification (III or IV), Rutherford classification (IV, V and VI) and other characteristics when cited; and (15) anticoagulation/antiplatelet medication at baseline (n + percentage).
Procedure description The following data were extracted: (1) who performed the procedure (interventional radiologist, vascular surgeon or other); (2) experience defined (number of procedures performed or years of experience); (3) which procedure was performed (only PTA (balloon), PTA + stent placement or other); and (4) if the study was described in sufficient detail to permit its replication (if information was provided as stated in previous items 1–3).
Angiographic outcomes and complications data were extracted on how articles defined (1) technical success; (2) partial success/failure; (3) complete technical failure; (4) major complications; and (5) minor complications and how many successes, failures and complications occurred.
Follow-up and dropout patients The following data were extracted regarding follow-up: (1) a summary of follow-up time and scheme; (2) if all patients underwent the same follow-up (yes or no) and (3) were dropout patients adequately reported (yes or no, with or without reasons for dropout or unclear).
Clinical outcomes and predictive factors Data were extracted on the three previously defined outcome variables: (1) ulcer healing; (2) AFS (major of minor) or limb salvage and (3) overall survival at baseline and at least 1-year follow-up with a maximum of 5-year follow-up. Data on predictive factors either in terms of regression analysis (univariate or multivariate) were extracted.
All data at baseline were presented as number plus percentage, with the exception of age, which is presented as a mean. Because standard deviation was not available in all datasets, result on baseline could not be pooled.
Data on ulcer healing, AFS and overall survival at baseline and at least 1-year follow-up were recorded. Data on predictive factors for ulcer healing, AFS (also limb salvage) and survival were extracted as reported in papers. As anticipated, the number of studies was limited. The data were heterogeneously presented so even meta-analysis with random effect approach would not be suitable for pooling predictive values. All data are therefore presented per study.
Search, Selection and Inclusion of Relevant Articles
The search yielded 1635 studies: 734 from Pubmed and 901 from EMBASE (see Appendix 1).
After excluding duplicates (240), letters/comments/editorials (57), conferences (354), case reports (42), other languages than English, Dutch, French or German (38), reviews and guidelines (228), study protocols (7), articles not involving CLI (37) and seven articles of which the full article could not be obtained, 625 articles on CLI remained.
Subsequently, articles were excluded based on title and abstract because they had less than 50 patients (136), they did not undergo PTA (152), were retrospective in nature (146) or had less than 1 year of follow-up (8) which yielded 183 potentially relevant articles. Full texts of these articles were checked on inclusion criteria: 173 articles did not meet the inclusion criteria and ten studies were included for data extraction (see Fig. 1) [21,22,23,24,25,26,27,28,29,30].
Study Design Characteristics
Of the ten articles included, all were cohort studies; most studies were performed based on prospective-designed databases and were single center. In all studies, there was no role of funders (see Table 1).
The patient selection was consecutive in most of the studies. In all studies, patients were included with CLI; however, the spectrum of patients was equivocal, as in one study only patients > 80 years were included , only diabetic patients , only hemodialysis patients  or patients with Rutherford V and VI  (see Table 2).
Baseline Patient Characteristics
In total, 2448 patients were included who were CLI patients and underwent PTA with or without bare metal stent placement. Mean ages ranged from 50 to 85.9 years. Male-to-female ratio was 816:534 in the seven studies mentioning this ratio [21,22,23, 27,28,29,30]. In addition, a broad range of risk factors was present: smoking rate from 6.9 to 58.3%, diabetes from 49.1 to 100%, hypertension from 51.6 to 98%, dyslipidaemia from 21.1 to 65% and renal disease up to 100%. Other risk factors such as coronary artery disease, cerebrovascular disease and stroke were also present in the majority of patients (see Table 3).
ABI was mentioned in only small number of studies, other measurements such as toe pressure and ankle pressure were only mentioned in the study of Strom et al. (toe pressure mean 30 mmHg [range 0–60 mmHg] and ankle pressure mean 50 mmHg [range 0–60 mmHg]) . The TcPO2 was not mentioned in any of the studies. The disease severity in terms of Fontaine classification or Rutherford category was described heterogeneously (see Table 4).
Procedure Description, Outcomes and Complications
In most studies, it was not clear who performed the procedure. Moreover, the experience of the operator was not defined in any of the studies. In none of the studies, the procedure was described in sufficient detail to replicate. The angiographic outcome in terms of technical success was defined well, and complications were reported in detail.
All data on procedure description and outcomes are given in detail in Table 5.
Follow-Up and Dropout Patients
The follow-up was not homogeneous, but in general 1 month, 3-, 6- and 12-month follow-up was done. Patients did not undergo the same follow-up in seven studies, while in three studies patients did undergo the same follow-up. Dropout rates are poorly reported. Only one study  accurately reported dropouts, with missing baseline information as most frequent reason for dropout. Follow-up ranged from less than 1 month up to 109 months. All details are given in Table 6.
Clinical Outcomes: Ulcer Healing, AFS/Limb Salvage and Survival
AFS or Limb Salvage
In all studies [21,22,23,24,25,26,27,28,29,30], data on AFS or limb salvage were given. One-year AFS ranged from 49.5 to 75.2%, 2-year AFS from 37 to 58% and 3-year AFS from 22 to 59%. The limb salvage rates for 1 month, 1 year, 2 year and 3 year range from 95 to 97.4%, 71 to 95%, 54 to 93.3% and 32 to 92.7%, respectively. All data are given in Table 8.
Survival rates were described in nine studies [21,22,23,24,25,26,27,28,29] with at least 3-year follow-up in most of the studies (see Table 9). The survival rates for 1 month, 1 year, 2 years and 3 years range from 94 to 100%, 65.4 to 91.5%, 45.7 to 76% and 37.3 to 83.1%, respectively.
When data were available on predictive values, these data were also extracted (see Table 10). However, these data were presented heterogeneously. We extracted all data as given in the studies. In general for univariate analysis, data were given either (1) at a time point (e.g., AFS at 2 years) by Fisher exact test or Chi-square test (2 × 2 tables) or Student’s t test (continuous normally distributed data) or Mann–Whitney tests (continuous not normally distributed data) or by association tests (continuous data) or (2) as time dependent by Kaplan–Meier analysis (with log rank test, for binary data) or Cox regression analysis (for multinomial or continuous data). Finally, multivariate analysis in either stepwise multiple regression analysis was used (at one time point) or Cox proportional regression analysis (for time dependent data) was performed.
Predictive Factors in Ulcer Healing
Predictive Factors in AFS or Limb Salvage
Predictive factors for AFS or limb salvage were reported in nine studies [21, 23,24,25,26,27,28,29,30]. All studies had different univariate and multivariate outcomes; however, age and diabetes were found to be significant predictors in at least three studies [21, 23, 24, 27]. See details in Table 10.
Predictive Factors in Survival Analysis
Also for the survival analysis, different predictive factors were found; however, age was found in 2 [22, 25] out of 5 studies reporting on predictive factors (see Table 10). Based on these findings, age and diabetes should be at least taken into account when searching for predictive factors.
In this review, we summarized the findings on predictive factors for wound healing, AFS and survival in CLI patients who underwent a PTA. As stated, the data were heterogeneously reported and presented. In addition, none of the studies found the same predictive factors. However, in several studies age and diabetes were found as predictive factors for AFS or limb salvage and survival. Several univariate studies showed age and diabetes as predictors [12, 31,32,33].
Compared with Other Studies
To our knowledge, no such systematic review has been published. There is a review  in which the authors summarized risk stratification models for CLI with a summary of the respective strengths and limitations of each. These models were developed from prospective cohorts to identify and quantify variables that can subsequently predict outcome in individual patients. In the prospective cohort, treatment options generally were compared (e.g., open and endovascular therapies) and new therapeutics were evaluated. The outcomes were not specific for defining risk models in patients with CLI patients undergoing PTA.
Strength of this Review
The major strength of our study is that we focussed on patients with CLI who underwent PTA to identify possible predictive factors for clinically relevant outcomes. We have done this to create a homogeneous and clinically relevant population, in order to draw conclusions.
We included studies which aimed to study predictive values of all types of risk factors. In addition, we only selected prospective studies or studies that used a prospective database, to have a predefined design without missing a lot of data. It is known that missing data are much more common in retrospective studies, in which routinely collected data are subsequently used for a different purpose .
Limitations of this Review
Although all studies were performed prospectively or a prospective database was present with a spectrum of patients which are represented, the data were presented too heterogeneously. Even the AFS or survival analysis was not reported homogeneously. The presented data on the predictive values varied even more, making general conclusions difficult.
Conclusion and Recommendations
It is not clear which risk factors should be taken into account. However, in several studies two factors, age and diabetes, were found as predictive factors for AFS or limb salvage and survival in patients with CLI undergoing PTA. Therefore, we believe that these factors should be taken into account in the future when searching for predictive factors and when analyzing study data on endovascular treatments for CLI. More research on this topic is needed. A trial with registry of all risk factors and the outcomes up to 12 months would be very important. Future research is needed to simplify and improve the accuracy and generalizability of risk stratification in CLI.
Michaels J. Second European Consensus Document on chronic critical leg ischemia. Eur J Vasc Surg. 1992;6 Suppl A:1–32.
Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG, TASC II Working Group. Inter-society consensus for the management of peripheral arterial disease (TASC II). J Vasc Surg. 2007;45 Suppl S:S5–67.
Feiring AJ. Footnotes on critical limb ischemia. J Am Coll Cardiol. 2008;51(20):1975–6.
Teraa M, Conte MS, Moll FL, Verhaar MC. Critical limb ischemia: current trends and future directions. J Am Heart Assoc. 2016;5(2):e002938. doi:10.1161/JAHA.115.002938.
Blevins WA Jr, Schneider PA. Endovascular management of critical limb ischemia. Eur J Vasc Endovasc Surg. 2010;39(6):756–61.
Beard JD. Which is the best revascularization for critical limb ischemia: endovascular or open surgery? J Vasc Surg. 2008;48(6 Suppl):11S–6S.
Söderström MI, Arvela EM, Korhonen M, Halmesmäki KH, Albäck AN, Biancari F, et al. Infrapopliteal percutaneous transluminal angioplasty versus bypass surgery as first-line strategies in critical leg ischemia: a propensity score analysis. Ann Surg. 2010;252(5):765–73.
Conrad MF, Kang J, Cambria RP, Brewster DC, Watkins MT, Kwolek CJ, et al. Infrapopliteal balloon angioplasty for the treatment of chronic occlusive disease. J Vasc Surg. 2009;50(4):799.e4–805.e4.
Haider SN, Kavanagh EG, Forlee M, Colgan MP, Madhavan P, Moore DJ, et al. Two-year outcome with preferential use of infrainguinal angioplasty for critical ischemia. J Vasc Surg. 2006;43(3):504–12.
Faglia E, Dalla Paola L, Clerici G, Clerissi J, Graziani L, Fusaro M, et al. Peripheral angioplasty as the first-choice revascularization procedure in diabetic patients with critical limb ischemia: prospective study of 993 consecutive patients hospitalized and followed between 1999 and 2003. Eur J Vasc Endovasc Surg. 2005;29(6):620–7.
Dosluoglu HH, Lall P, Harris LM, Dryjski ML. Long-term limb salvage and survival after endovascular and open revascularization for critical limb ischemia after adoption of endovascular-first approach by vascular surgeons. J Vasc Surg. 2012;56(2):361–71.
Faglia E, Clerici G, Airoldi F, Tavano D, Caminiti M, Curci V, et al. Revascularization by angioplasty of type D femoropopliteal and long infrapopliteal lesion in diabetic patients with critical limb ischemia: are TASC II recommendations suitable? A population-based cohort study. Int J Low Extrem Wounds. 2012;11(4):277–85.
Gallagher KA, Meltzer AJ, Ravin RA, Graham A, Shrikhande G, Connolly PH, et al. Endovascular management as first therapy for chronic total occlusion of the lower extremity arteries: comparison of balloon angioplasty, stenting, and directional atherectomy. J Endovasc Ther. 2011;18(5):624–37. Erratum in: J Endovasc Ther. 2011;18(6):A-5.
Iida O, Soga Y, Yamauchi Y, Hirano K, Kawasaki D, Yamaoka T, et al. Clinical efficacy of endovascular therapy for patients with critical limb ischemia attributable to pure isolated infrapopliteal lesions. J Vasc Surg. 2013;57(4):974.e1–981.e1.
Tomoi Y, Soga Y, Iida O, Hirano K, Suzuki K, Kawasaki D, et al. Efficacy of statin treatment after endovascular therapy for isolated below-the-knee disease in patients with critical limb ischemia. Cardiovasc Interv Ther. 2013;28(4):374–82.
Rastan A, Tepe G, Krankenberg H, Zahorsky R, Beschorner U, Noory E, et al. Sirolimus-eluting stents vs. bare-metal stents for treatment of focal lesions in infrapopliteal arteries: a double-blind, multi-centre, randomized clinical trial. Eur Heart J. 2011;32(18):2274–81.
Schmidt A, Ulrich M, Winkler B, Klaeffling C, Bausback Y, Bräunlich S, et al. Angiographic patency and clinical outcome after balloon-angioplasty for extensive infrapopliteal arterial disease. Catheter Cardiovasc Interv. 2010;76(7):1047–54.
Treiman GS, Treiman R, Whiting J. Results of percutaneous subintimal angioplasty using routine stenting. J Vasc Surg. 2006;43(3):513–9.
Smith BM, Stechman M, Gibson M, Torrie EP, Magee TR, Galland RB. Subintimal angioplasty for superficial femoral artery occlusion: poor patency in critical ischaemia. Ann R Coll Surg Engl. 2005;87(5):361–5.
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;21(339):b2700.
Arvela E, Venermo M, Söderström M, Korhonen M, Halmesmäki K, Albäck A, et al. Infrainguinal percutaneous transluminal angioplasty or bypass surgery in patients aged 80 years and older with critical leg ischaemia. Br J Surg. 2011;98(4):518–26.
Bargellini I, Petruzzi P, Scatena A, Cioni R, Cicorelli A, Vignali C, et al. Primary infrainguinal subintimal angioplasty in diabetic patients. Cardiovasc Interv Radiol. 2008;31(4):713–22.
Davies MG, El-Sayed HF. Outcomes of isolated tibial endovascular interventions for tissue loss in CLI patients on hemodialysis. J Endovasc Ther. 2015;22(5):681–9.
Dick F, Diehm N, Galimanis A, Husmann M, Schmidli J, Baumgartner I. Surgical or endovascular revascularization in patients with critical limb ischemia: influence of diabetes mellitus on clinical outcome. J Vasc Surg. 2007;45(4):751–61.
Lo RC, Darling J, Bensley RP, Giles KA, Dahlberg SE, Hamdan AD, et al. Outcomes following infrapopliteal angioplasty for critical limb ischemia. J Vasc Surg. 2013;57(6):1455–63 discussion 1463-4.
Mathur K, Ayyappan MK, Hodson J, Hopkins J, Tiwari A, Duddy M, et al. Factors affecting medium-term outcomes after crural angioplasty in critically ischemic legs. Vasc Endovascular Surg. 2015;49(3–4):63–8.
Nakano M, Hirano K, Yamauchi Y, Iida O, Soga Y, Kawasaki D, et al. Three-year clinical outcome after infrapopliteal angioplasty for critical limb ischemia in hemodialysis patients with minor or major tissue loss. Catheter Cardiovasc Interv. 2015;86(2):289–98.
Okamoto S, Iida O, Nakamura M, Yamauchi Y, Fukunaga M, Yokoi Y, et al. Postprocedural skin perfusion pressure correlates with clinical outcomes 1 year after endovascular therapy for patients with critical limb ischemia. Angiology. 2015;66(9):862–6.
Siablis D, Karnabatidis D, Katsanos K, Diamantopoulos A, Spiliopoulos S, Kagadis GC, Tsolakis J. Infrapopliteal application of sirolimus-eluting versus bare metal stents for critical limb ischemia: analysis of long-term angiographic and clinical outcome. J Vasc Interv Radiol. 2009;20(9):1141–50.
Strøm M, Konge L, Lönn L, Schroeder TV, Rørdam P. Amputation-free survival after crural percutaneous transluminal angioplasty for critical limb ischemia. Scand J Surg. 2016;105(1):42–8.
Bakken AM, Palchik E, Hart JP, Rhodes JM, Saad WE, Davies MG. Impact of diabetes mellitus on outcomes of superficial femoral artery endoluminal interventions. J Vasc Surg. 2007;46(5):946–58 discussion 958.
Brosi P, Dick F, Do DD, Schmidli J, Baumgartner I, Diehm N. Revascularization for chronic critical lower limb ischemia in octogenarians is worthwhile. J Vasc Surg. 2007;46(6):1198–207.
Setacci F, Sirignano P, Raucci A, de Donato G, Chisci E, Galzerano G, et al. Below the knee endovascular revascularization strategy for limb salvage in diabetic patients. Ital J Vasc Endovasc Surg. 2010;17(3):189–94.
Chung J, Modrall JG, Valentine RJ. The need for improved risk stratification in chronic critical limb ischemia. J Vasc Surg. 2014;60(6):1677–85.
Altman DG, Bland JM. Missing data. BMJ. 2007;334(7590):424.
Conflict of interest
S.M. Schreuder, Y.M.G.A. Hendrix, J.A. Reekers and S. Bipat declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
Does not apply.
See Table 11.
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Cite this article
Schreuder, S.M., Hendrix, Y.M., Reekers, J.A. et al. Predictive Parameters for Clinical Outcome in Patients with Critical Limb Ischemia Who Underwent Percutaneous Transluminal Angioplasty (PTA): A Systematic Review. Cardiovasc Intervent Radiol 41, 1–20 (2018). https://doi.org/10.1007/s00270-017-1796-9
- Amputation free survival