Development of a Searchable Database of Cryoablation Simulations for Use in Treatment Planning
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To create and validate a planning tool for multiple-probe cryoablation, using simulations of ice ball size and shape for various ablation probe configurations, ablation times, and types of tissue ablated.
Materials and Methods
Ice ball size and shape was simulated using the Pennes bioheat equation. Five thousand six hundred and seventy different cryoablation procedures were simulated, using 1–6 cryoablation probes and 1–2 cm spacing between probes. The resulting ice ball was measured along three perpendicular axes and recorded in a database. Simulated ice ball sizes were compared to gel experiments (26 measurements) and clinical cryoablation cases (42 measurements). The clinical cryoablation measurements were obtained from a HIPAA-compliant retrospective review of kidney and liver cryoablation procedures between January 2015 and February 2016. Finally, we created a web-based cryoablation planning tool, which uses the cryoablation simulation database to look up the probe spacing and ablation time that produces the desired ice ball shape and dimensions.
Average absolute error between the simulated and experimentally measured ice balls was 1 mm in gel experiments and 4 mm in clinical cryoablation cases. The simulations accurately predicted the degree of synergy in multiple-probe ablations. The cryoablation simulation database covers a wide range of ice ball sizes and shapes up to 9.8 cm.
Cryoablation simulations accurately predict the ice ball size in multiple-probe ablations. The cryoablation database can be used to plan ablation procedures: given the desired ice ball size and shape, it will find the number and type of probes, probe configuration and spacing, and ablation time required.
KeywordsCryoablation Simulation Prediction Planning
- 11.http://www.galilmedical.com/cryoablation-products/ifus/. Accessed 10 Feb 2015.
- 21.Hasgall PA, Di Gennaro F, Baumgartner C, et al. IT’IS database for thermal and electromagnetic parameters of biological tissues. 2015. http://www.itis.ethz.ch/itis-for-health/tissue-properties/downloads/. Accessed 01 Sept 2015.
- 22.Kreith F, Goswami DY. The CRC handbook of mechanical engineering. Boca Raton: CRC Press; 2005.Google Scholar
- 23.Lide DR. CRC handbook of chemistry and physics. Boca Raton: CRC Press; 2000.Google Scholar
- 24.WolframAlpha. http://www.wolframalpha.com. Accessed 2015.
- 25.Snyder WS, Cook MJ, Nasset ES, Karhausen LR, Howells GP, Tipton IH. Report of the task group on reference man. Ann ICRP. 1975;23:1–480.Google Scholar