Endovascular Therapy Research in Lower Limb Peripheral Arterial Disease Published Over a 5-Year Period: Who is Publishing and Where?



Peripheral arterial disease (PAD) is being increasingly managed by endovascular therapies. In this study, we identified the clinical services publishing research as well as the journals of publication over a 5-year period.


Twenty keywords and phrases related to endovascular intervention were identified, and a literature search was performed through the PubMed database from January 2009 to January 2014. Inclusion criteria were English language, study population more than five patients, and matching the keyword search. Eligible studies were collated into a database and classified by journal of publication, PubMed number, article title, publishing clinical service, type of publication, country of origin, and authors.


825 studies from 114 different journals were identified. 297 papers were excluded. Of the 528 included papers, 204 (39%) were published by Vascular Surgery (VS), 157 (30%) by Interventional Radiology (IR), 101 (19%) by Cardiology, 43 (8%) by Angiology, 6 (1%) by Vascular Medicine, and 17 (3%) from miscellaneous services. 283 (54%) studies originated from Europe, 157 (30%) from North America, 76 (14%) from Asia, 6 from Australia, 3 each from South America and Africa. IR published the most papers on PAD endovascular intervention in Europe with VS second while this trend was reversed in the USA. The 528 papers were published in 98 different journals with retrospective case series (72%), the majority.


IR continues to play a significant research role in endovascular intervention in PAD, particularly in Europe, and specifically in below the knee intervention, pedal intervention, and drug-eluting technologies.

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  1. 1.

    Balk E, Cepeda M, Ip S, Trikalinos T, O’Donnell T. Horizon Scan of invasive interventions for lower extremity peripheral artery disease and systematic review of studies comparing stent placement to other interventions. 2008. Rockville (MD): Agency for Healthcare Research and Quality (US).

  2. 2.

    Gloviczki P. Vascular and endovascular surgeon: the vascular specialist for the 21st century and beyond. J Vasc Surg. 2006;43(2):412–21.

    Article  PubMed  Google Scholar 

  3. 3.

    Anderson PL, Gelijns A, Moskowitz A, Arons R, Gupta L, Weinberg A, et al. Understanding trends in inpatient surgical volume: vascular interventions, 1980–2000. J Vasc Surg. 2004;39(6):1200–8.

    Article  PubMed  Google Scholar 

  4. 4.

    Selvin E, Erlinger TP. Prevalence of and risk factors for peripheral arterial disease in the United States results from the national health and nutrition examination survey, 1999–2000. Circulation. 2004;110(6):738–43.

    Article  PubMed  Google Scholar 

  5. 5.

    Nowygrod R, Egorova N, Greco G, Anderson P, Gelijns A, Moskowitz A, et al. Trends, complications, and mortality in peripheral vascular surgery. J Vasc Surg. 2006;43(2):205–16.

    Article  PubMed  Google Scholar 

  6. 6.

    Berglund J, Björck M, Elfström J. Long-term results of above knee femoro-popliteal bypass depend on indication for surgery and graft-material. Eur J Vasc Endovasc Surg. 2005;29(4):412–8.

    CAS  Article  PubMed  Google Scholar 

  7. 7.

    Langham MC, Zhou Y, Chirico EN, Magland JF, Sehgal CM, Englund EK, et al. Effects of age and smoking on endothelial function assessed by quantitative cardiovascular magnetic resonance in the peripheral and central vasculature. J Cardiovasc Magn Reson. 2015;17(1):19.

    Article  PubMed  PubMed Central  Google Scholar 

  8. 8.

    Agrawal R, Ola V, Bishnoi P, Gothwal S, Sirohi P, Agrawal R. Prevalence of Micro and Macrovascular Complications and their Risk Factors in Type-2 Diabetes Mellitus. JAPI. 2014;62:505.

    Google Scholar 

  9. 9.

    Coran AG, Warren R. Arteriographic changes in femoropopliteal arteriosclerosis obliterans: A five-year follow-up study. N Engl J Med. 1966;274(12):643–7.

    CAS  Article  PubMed  Google Scholar 

  10. 10.

    Palmaz JC, Richter GM, Noeldge G, Schatz RA, Robison PD, Gardiner GA Jr, Becker GJ, McLean GK, Denny DF Jr, Lammer J. Intraluminal stents in atherosclerotic iliac artery stenosis: preliminary report of a multicenter study. Radiology. 1988;168(3):727–31.

    CAS  Article  PubMed  Google Scholar 

  11. 11.

    Rousseau HP, Raillat CR, Joffre FG, Knight CJ, Ginestet MC. Treatment of Femoropopliteal Stenoses by means of self-expandable endoprostheses: midterm results 1. Radiology. 1989;172(3):961–4.

    CAS  Article  PubMed  Google Scholar 

  12. 12.

    Rösch J, Keller FS, Kaufman JA. The birth, early years, and future of interventional radiology. J Vasc Interv Radiol. 2003;14(7):841–53.

    Article  PubMed  Google Scholar 

  13. 13.

    Duda SH, Pusich B, Richter G, Landwehr P, Oliva VL, Tielbeek A, Wiesinger B, Hak JB, Tielemans H, Ziemer G, Cristea E. Sirolimus-eluting stents for the treatment of obstructive superficial femoral artery disease six-month results. Circulation. 2002;106(12):1505–9.

    CAS  Article  PubMed  Google Scholar 

  14. 14.

    Tepe G, Zeller T, Albrecht T, Heller S, Schwarzwälder U, Beregi JP, Claussen MC, Oldenburg A, Scheller B, Speck U. Local delivery of paclitaxel to inhibit restenosis during angioplasty of the leg. N Engl J Med. 2008;358(7):689–99.

    CAS  Article  PubMed  Google Scholar 

  15. 15.

    Dotter CT, Judkins MP. Transluminal treatment of arteriosclerotic obstruction description of a new technic and a preliminary report of its application. Circulation. 1964;30(5):654–70.

    CAS  Article  PubMed  Google Scholar 

  16. 16.

    Bollinger A, Schlumpf M. Andreas Grüntzig’s balloon catheter for angioplasty of peripheral arteries (PTA) is 25 years old. Vasa. 1999;28(1):58–64.

    CAS  Article  PubMed  Google Scholar 

  17. 17.

    Bosch JL, Hunink MG. Meta-analysis of the results of percutaneous transluminal angioplasty and stent placement for aortoiliac occlusive disease. Radiology. 1997;204(1):87–96.

    CAS  Article  PubMed  Google Scholar 

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Asadi, H., Lee, R.J., Sheehan, M. et al. Endovascular Therapy Research in Lower Limb Peripheral Arterial Disease Published Over a 5-Year Period: Who is Publishing and Where?. Cardiovasc Intervent Radiol 40, 343–350 (2017). https://doi.org/10.1007/s00270-016-1504-1

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  • Endovascular intervention
  • Peripheral arterial disease
  • Interventional radiology
  • Vascular surgery
  • Research
  • Randomised controlled trials