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Proximal Occlusion of Medium-Sized Vessels with the Penumbra Occlusion Device: A Study of Safety and Efficacy

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Abstract

Purpose

To retrospectively investigate the safety and efficacy of hybrid proximal coiling of various medium-sized vessels (4 to 8 mm) using the Penumbra Occlusion Device (POD).

Materials and Methods

From October 2014 to February 2016, 37 proximal embolizations were performed with PODs in 36 patients (mean age: 50.8, range: 10–86; 29 male, 7 female). Vessel occlusions were achieved under fluoroscopic guidance using a 2.7 French microcatheter. Among the 36 vessels targeted, 16 were splenic arteries, 11 renal arteries, 4 mesenteric arteries, 3 arteriovenous fistulae, 1 iliac artery, and 1 gonadal vein. Intermittent follow-up angiography was performed to assess the flow for final occlusion. Outcomes and complications were assessed by clinical and/or imaging follow-up.

Results

To produce proximal occlusion of the intended vessels, the POD was used alone in 19 embolizations (51.4 %). In 12 procedures (32.4 %), POD was used as a coil constrainer to secure the coil construct. In 6 procedures (16.2 %), additional embolic devices were used to achieve vessel occlusion after initial POD deployment. After a mean follow-up of 3.2 months, no POD migration was observed but two complications occurred (5.4 %): one post embolic syndrome and one extensive infarction with splenic abscess.

Conclusion

The POD system allows safe and effective proximal embolization of medium-sized vessels in a variety of clinical settings.

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Acknowledgments

The authors thank Pippa McKelvie-Sebileau for medical editorial assistance in English.

Funding

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Authors and Affiliations

  1. Department of Radiology, Pellegrin Hospital, Place Amélie Raba Léon, 33076, Bordeaux, France

    E. Jambon, F. Petitpierre, Y. Le Bras, N. Grenier & F. Cornelis

  2. Department of Surgery, Pellegrin Hospital, Place Amélie Raba Léon, 33076, Bordeaux, France

    V. Brizzi & V. Dubuisson

Authors
  1. E. Jambon
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  2. F. Petitpierre
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  3. V. Brizzi
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  4. V. Dubuisson
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  5. Y. Le Bras
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  6. N. Grenier
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  7. F. Cornelis
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Corresponding author

Correspondence to F. Cornelis.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

For this retrospective study, formal consent was not required. The Institutional Review Board approved this retrospective study and the waiver for obtaining informed consent for this review of recorded patient data.

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Jambon, E., Petitpierre, F., Brizzi, V. et al. Proximal Occlusion of Medium-Sized Vessels with the Penumbra Occlusion Device: A Study of Safety and Efficacy. Cardiovasc Intervent Radiol 40, 210–215 (2017). https://doi.org/10.1007/s00270-016-1480-5

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  • DOI: https://doi.org/10.1007/s00270-016-1480-5

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