CardioVascular and Interventional Radiology

, Volume 39, Issue 10, pp 1372–1378

Comparative Study Using 100–300 Versus 300–500 μm Microspheres for Symptomatic Patients Due to Enlarged-BPH Prostates

  • Octavio Meneghelli Gonçalves
  • Francisco Cesar Carnevale
  • Airton Mota Moreira
  • Alberto Azoubel Antunes
  • Vanessa Cristina Rodrigues
  • Miguel Srougi
Clinical Investigation

Abstract

Purpose

The purpose of the study was to compare safety and efficacy outcomes following prostate artery embolization (PAE) for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) with 100–300 versus 300–500 μm tris-acryl gelatin microspheres.

Materials and Methods

Patients were prospectively treated between August 2011 and June 2013 to receive PAE with 100–300 μm (group A) or 300–500 μm (group B) tris-acryl gelatin microspheres. Patients were followed for a minimum of 12 months and were assessed for changes in International Prostate Symptom Score (IPSS), quality of life (QoL) index, prostate volume determined by magnetic resonance imaging, serum prostate specific antigen (PSA), and maximum urine flow rate (Qmax), as well as any treatment-related adverse events.

Results

Fifteen patients were included in each group, and PAE was technically successful in all cases. Both groups experienced significant improvement in mean IPSS, QoL, prostate volume, PSA, and Qmax (p < 0.05 for all). The differences observed between the two groups included a marginally insignificant more adverse events (p = 0.066) and greater mean serum PSA reduction at 3 months of follow-up (p = 0.056) in group A.

Conclusions

Both 100–300 and 300–500 μm microspheres are safe and effective embolic agents for PAE to treat LUTS-related to BPH. Although functional and imaging outcomes did not differ significantly following use of the two embolic sizes, the greater incidence of adverse events with 100–300 μm microspheres suggests that 300–500 μm embolic materials may be more appropriate.

Keywords

Arterial intervention Embolization Embolotherapy Prostate 

Abbreviations

BPH

Benign prostatic hyperplasia

BOO

Bladder outlet obstruction

IPSS

International Prostate Symptom Score

LUTS

Lower urinary tract symptoms

MRI

Magnetic resonance imaging

Qmax

Maximum urinary flow rate

PVA

Polyvinyl alcohol

PSA

Prostate-specific antigen

PAE

Prostatic artery embolization

QoL

Quality of life index

TURP

Transurethral resection of the prostate

Copyright information

© Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2016

Authors and Affiliations

  • Octavio Meneghelli Gonçalves
    • 1
  • Francisco Cesar Carnevale
    • 1
  • Airton Mota Moreira
    • 1
  • Alberto Azoubel Antunes
    • 2
  • Vanessa Cristina Rodrigues
    • 1
  • Miguel Srougi
    • 2
  1. 1.Interventional Radiology UnitUniversity of Sao Paulo Medical SchoolSao PauloBrazil
  2. 2.Division of UrologyUniversity of Sao Paulo Medical SchoolSao PauloBrazil

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