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Renal Angiomyolipoma: Mid- to Long-Term Results Following Embolization with Onyx

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Abstract

Purpose

Percutaneous transcatheter embolization is currently the preferred treatment for ruptured or enlarging renal angiomyolipoma (AML), although the optimum choice of embolic material has not yet been established. We present mid- to long-term outcomes following embolization of AMLs with Onyx.

Materials and Methods

Ten AMLs in seven patients (including two with tuberous sclerosis) were embolized with Onyx. Patients were followed-up clinically, with tumour size and renal function measured pre- and post-procedure.

Results

Mean pre-treatment AML size was 63.4 mm (range 42–100). Mean clinical follow-up was 431.4 days (range 153–986) and imaging follow-up 284.2 days (range 30–741). There was no haemorrhage from treated lesions within the follow-up period. Of patients who had cross-sectional imaging pre- and post-procedure, mean decrease in AML size of 22 mm was seen after Onyx embolization (p = 0.0058, 95 % CI 9.13–34.87). No significant difference between serum creatinine was seen pre- and post-procedure (p = 0.54, 95 % CI 8.63–4.85).

Conclusions

Onyx embolization of renal AMLs is effective in the medium to long term, with theoretical benefits in safety and durability of result.

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Authors and Affiliations

  1. Department of Interventional Radiology, Guy’s & St Thomas’ NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, UK

    Narayanan Thulasidasan, Srividhiya Sriskandakumar, Shahzad Ilyas & Tarun Sabharwal

Authors
  1. Narayanan Thulasidasan
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  2. Srividhiya Sriskandakumar
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  3. Shahzad Ilyas
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  4. Tarun Sabharwal
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Correspondence to Narayanan Thulasidasan.

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On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

All procedures performed were in accordance with the ethical standards of the institutional and national research committee, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Thulasidasan, N., Sriskandakumar, S., Ilyas, S. et al. Renal Angiomyolipoma: Mid- to Long-Term Results Following Embolization with Onyx. Cardiovasc Intervent Radiol 39, 1759–1764 (2016). https://doi.org/10.1007/s00270-016-1432-0

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  • DOI: https://doi.org/10.1007/s00270-016-1432-0

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