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Change in Imaging Findings on Angiography-Assisted CT During Balloon-Occluded Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma

  • Clinical Investigation
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Abstract

Purpose

To evaluate changes in imaging findings on CT during hepatic arteriography (CTHA) and CT during arterial portography (CTAP) by balloon occlusion of the treated artery and their relationship with iodized oil accumulation in the tumor during balloon-occluded transcatheter arterial chemoembolization (B-TACE).

Methods

Both B-TACE and angiography-assisted CT were performed for 27 hepatocellular carcinomas. Tumor enhancement on selective CTHA with/without balloon occlusion and iodized oil accumulation after B-TACE were evaluated. Tumorous portal perfusion defect size on CTAP was compared with/without balloon occlusion. Factors influencing discrepancies between selective CTHA with/without balloon occlusion and the degree of iodized oil accumulation were investigated.

Results

Among 27 tumors, tumor enhancement on selective CTHA changed after balloon occlusion in 14 (decreased, 11; increased, 3). In 18 tumors, there was a discrepancy between tumor enhancement on selective CTHA with balloon occlusion and the degree of accumulated iodized oil, which was higher than the tumor enhancement grade in all 18. The tumorous portal perfusion defect on CTAP significantly decreased after balloon occlusion in 18 of 20 tumors (mean decrease from 21.9 to 19.1 mm in diameter; p = 0.0001). No significant factors influenced discrepancies between selective CTHA with/without balloon occlusion. Central area tumor location, poor tumor enhancement on selective CTHA with balloon occlusion, and no decrease in the tumorous portal perfusion defect area on CTAP after balloon occlusion significantly influenced poor iodized oil accumulation in the tumor.

Conclusions

Tumor enhancement on selective CTHA frequently changed after balloon occlusion, which did not correspond to accumulated iodized oil in most cases.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, Institute and Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minamiku, Hiroshima, 734-8551, Japan

    Rika Yoshimatsu, Takuji Yamagami, Masaki Ishikawa, Kenji Kajiwara & Kazuo Awai

  2. Department of Radiology, Kochi University, Kohasu, Okocho, Nankoku, Kochi, 783-8505, Japan

    Rika Yoshimatsu & Takuji Yamagami

  3. Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minamiku, Hiroshima, 734-8551, Japan

    Hiroshi Aikata & Kazuaki Chayama

Authors
  1. Rika Yoshimatsu
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  2. Takuji Yamagami
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  3. Masaki Ishikawa
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  4. Kenji Kajiwara
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  5. Hiroshi Aikata
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  6. Kazuaki Chayama
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  7. Kazuo Awai
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Corresponding author

Correspondence to Takuji Yamagami.

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Conflict of Interest

Dr. Chayama receives honoraria (more than 1,000,000 yen) or research funding (more than 2,000,000 yen) from MSD Co., Ltd., Tanabe Co., Ltd., Roche Co., Ltd., Toray Co., Ltd., Chugai Co., Ltd., Sumitomo Co., Ltd., Otuka Co., Ltd., and Daiichi-Sankyo Co., Ltd. Dr. Awai receives research funding (more than 2,000,000 yen) from Toshiba Medical Systems Co., Ltd. The other authors have no conflicts of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in this study.

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Yoshimatsu, R., Yamagami, T., Ishikawa, M. et al. Change in Imaging Findings on Angiography-Assisted CT During Balloon-Occluded Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma. Cardiovasc Intervent Radiol 39, 865–874 (2016). https://doi.org/10.1007/s00270-015-1279-9

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  • DOI: https://doi.org/10.1007/s00270-015-1279-9

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