CardioVascular and Interventional Radiology

, Volume 39, Issue 3, pp 367–375 | Cite as

Clinical Results After Prostatic Artery Embolization Using the PErFecTED Technique: A Single-Center Study

  • Gregory Amouyal
  • Nicolas Thiounn
  • Olivier Pellerin
  • Lin Yen-Ting
  • Costantino Del Giudice
  • Carole Dean
  • Helena Pereira
  • Gilles Chatellier
  • Marc Sapoval
Clinical Investigation

Abstract

Background

Prostatic artery embolization (PAE) has been performed for a few years, but there is no report on PAE using the PErFecTED technique outside from the team that initiated this approach.

Objective

This single-center retrospective open label study reports our experience and clinical results on patients suffering from symptomatic BPH, who underwent PAE aiming at using the PErFecTED technique.

Materials and Methods

We treated 32 consecutive patients, mean age 65 (52–84 years old) between December 2013 and January 2015. Patients were referred for PAE after failure of medical treatment and refusal or contra-indication to surgery. They were treated using the PErFecTED technique, when feasible, with 300–500 µm calibrated microspheres (two-night hospital stay or outpatient procedure). Follow-up was performed at 3, 6, and 12 months.

Results

We had a 100 % immediate technical success of embolization (68 % of feasibility of the PErFecTED technique) with no immediate complications. After a mean follow-up of 7.7 months, we observed a 78 % rate of clinical success. Mean IPSS decreased from 15.3 to 4.2 (p = .03), mean QoL from 5.4 to 2 (p = .03), mean Qmax increased from 9.2 to 19.2 (p = .25), mean prostatic volume decreased from 91 to 62 (p = .009) mL. There was no retrograde ejaculation and no major complication.

Conclusion

PAE using the PErFecTED technique is a safe and efficient technique to treat bothersome LUTS related to BPH. It is of interest to note that the PErFecTED technique cannot be performed in some cases for anatomical reasons.

Abbreviations

PAE

Prostatic artery embolization

BPH

Benign prostate hyperplasia

LUTS

Lower urinary track symptoms

IPSS

International prostatic symptoms score

IIEF

International index of erectile function

QoL

Quality of life

Qmax

Maximum urinary flow

PVR

Post-voiding residue

tPSA

total Prostate serum antigen

PV

Prostatic volume

PA

Prostatic artery

CBCT

Cone-beam computed tomography

Notes

Compliance with Ethical Standards

Conflict of Interest

Gregory Amouyal, Nicolas Thiounn, Olivier Pellerin, Lin Yen-Ting, Costantino Del Giudice, Carole Dean, Helena Pereira, and Gilles Chatellier have nothing to disclose; Marc Sapoval has financial support from Merit Medical (Salt lake city, USA) for attending/speaking at symposia/congresses and for educational programs.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in this study.

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Copyright information

© Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2015

Authors and Affiliations

  • Gregory Amouyal
    • 1
    • 2
  • Nicolas Thiounn
    • 1
    • 4
  • Olivier Pellerin
    • 1
    • 2
    • 3
  • Lin Yen-Ting
    • 2
  • Costantino Del Giudice
    • 1
    • 2
  • Carole Dean
    • 2
    • 3
  • Helena Pereira
    • 5
    • 6
  • Gilles Chatellier
    • 1
    • 6
  • Marc Sapoval
    • 1
    • 2
    • 3
  1. 1.Faculté de MédecineUniversité Paris Descartes - Sorbonne - Paris - CitéParisFrance
  2. 2.Interventional Radiology DepartmentAssistance Publique - Hôpitaux de Paris, Hôpital Européen Georges PompidouParisFrance
  3. 3.INSERM U970ParisFrance
  4. 4.Urology DepartmentAssistance Publique - Hôpitaux de Paris, Hôpital Européen Georges PompidouParisFrance
  5. 5.Clinical Research UnitAssistance Publique - Hôpitaux de Paris, Hôpital Européen Georges PompidouParisFrance
  6. 6.INSERM U1418ParisFrance

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