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Diagnostic Accuracy of MRI-guided Percutaneous Transthoracic Needle Biopsy of Solitary Pulmonary Nodules

  • Clinical Investigation
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Abstract

Objective

The purpose of our study was to evaluate the diagnostic accuracy of MRI-guided percutaneous transthoracic needle biopsy (PTNB) of solitary pulmonary nodules (SPNs).

Methods

Retrospective review of 69 patients who underwent MR-guided PTNB of SPNs was performed. Each case was reviewed for complications. The final diagnosis was established by surgical pathology of the nodule or clinical and imaging follow-up. Pneumothorax rate and diagnostic accuracy were compared between two groups according to nodule diameter (≤2 vs. >2 cm) using χ 2 chest and Fisher’s exact test, respectively.

Results

The success rate of single puncture was 95.6 %. Twelve (17.4 %) patients had pneumothorax, with 1 (1.4 %) requiring chest tube insertion. Mild hemoptysis occurred in 7 (7.2 %) patients. All of the sample material was sufficient for histological diagnostic evaluation. Pathological analysis of biopsy specimens showed 46 malignant, 22 benign, and 1 nondiagnostic nodule. The final diagnoses were 49 malignant nodules and 20 benign nodules basing on postoperative histopathology and clinical follow-up data. One nondiagnostic sample was excluded from calculating diagnostic performance. A sensitivity, specificity, accuracy, positive predictive value, and negative predictive value in diagnosing SPNs were 95.8, 100, 97.0, 100, and 90.9 %, respectively. Pneumothorax rate, diagnostic sensitivity, and accuracy were not significantly different between the two groups (P > 0.05).

Conclusions

MRI-guided PTNB is safe, feasible, and high accurate diagnostic technique for pathologic diagnosis of pulmonary nodules.

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Conflict of interest

All authors declare that we have no conflict of interest about this paper.

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Authors and Affiliations

  1. Department of Radiation Oncology, Shandong Cancer Hospital and Institute, School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Science, 440 Jiyan Road, Jinan, 250117, Shandong Province, China

    Shangang Liu, Xuejuan Yu, Tingyong Fan, Dong Chen, Pinliang Zhang & Ruimei Ren

  2. Department of Interventional MRI, Shandong Medical Imaging Research Institute, Shandong University, Weiqi Avenue, Jingwu Road, Jinan, 250021, Shandong Province, China

    Chengli Li & Ming Liu

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  1. Shangang Liu
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  2. Chengli Li
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  3. Xuejuan Yu
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  4. Ming Liu
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  6. Dong Chen
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  7. Pinliang Zhang
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Correspondence to Ruimei Ren.

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Liu, S., Li, C., Yu, X. et al. Diagnostic Accuracy of MRI-guided Percutaneous Transthoracic Needle Biopsy of Solitary Pulmonary Nodules. Cardiovasc Intervent Radiol 38, 416–421 (2015). https://doi.org/10.1007/s00270-014-0915-0

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  • DOI: https://doi.org/10.1007/s00270-014-0915-0

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