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CardioVascular and Interventional Radiology

, Volume 36, Issue 1, pp 237–238 | Cite as

Incompatibility of Contrast Medium and Trisodium Citrate

  • Christian Delcour
  • Guy Bruninx
Technical Note
  • 149 Downloads

Abstract

Purpose

To test the compatibility of trisodium citrate, a catheter lock solution, with iodinated contrast medium.

Methods

Iohexol, iobitridol, iodixanol, ioxaglate, ioxithalamate, iomeprol, and iopromide were tested. In all tests, 2 ml of contrast medium were mixed with 2 ml of trisodium citrate solution.

Results

Iodixanol and ioxaglate provoked a highly viscous gluelike precipitation when mixed with trisodium citrate. A brief transient precipitate was observed with iohexol, iomeprol, and ioxithalamate. Permanent precipitation occurred with iobitridol and iopromide.

Conclusion

One must be aware of the potential for precipitation when contrast medium is mixed with trisodium citrate solution. Before trisodium citrate solution is injected, the catheter should be thoroughly flushed with saline if a contrast medium has previously been injected through it.

Keywords

Angiography Complications Contrast media 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2012

Authors and Affiliations

  1. 1.Department of RadiologyCHU de CharleroiCharleroiBelgium

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