CardioVascular and Interventional Radiology

, Volume 36, Issue 1, pp 237–238 | Cite as

Incompatibility of Contrast Medium and Trisodium Citrate

  • Christian DelcourEmail author
  • Guy Bruninx
Technical Note



To test the compatibility of trisodium citrate, a catheter lock solution, with iodinated contrast medium.


Iohexol, iobitridol, iodixanol, ioxaglate, ioxithalamate, iomeprol, and iopromide were tested. In all tests, 2 ml of contrast medium were mixed with 2 ml of trisodium citrate solution.


Iodixanol and ioxaglate provoked a highly viscous gluelike precipitation when mixed with trisodium citrate. A brief transient precipitate was observed with iohexol, iomeprol, and ioxithalamate. Permanent precipitation occurred with iobitridol and iopromide.


One must be aware of the potential for precipitation when contrast medium is mixed with trisodium citrate solution. Before trisodium citrate solution is injected, the catheter should be thoroughly flushed with saline if a contrast medium has previously been injected through it.


Angiography Complications Contrast media 


Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2012

Authors and Affiliations

  1. 1.Department of RadiologyCHU de CharleroiCharleroiBelgium

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